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A reanalysis of the ICAR trial reveals that ARDS inflammatory subphenotypes remain remarkably stable over 28 days. The hyperinflammatory profile is linked to higher mortality and distinct biomarkers, with Bayesian modeling showing minimal t
A longitudinal study from the Dallas Heart Study identifies calprotectin as a significant, independent predictor of ASCVD events, linking neutrophil activation to endothelial dysfunction and increased cardiovascular risk across diverse popu
A large-scale multicenter study identifies unique multivariate patterns of peripheral inflammation and brain structure that differentiate early-stage depression and psychosis, highlighting the influence of childhood trauma and cognitive per
Elevated VCAM-1 levels correlate with worse outcomes in chronic HFrEF, independent of conventional markers; dapagliflozin’s benefits are consistent across VCAM-1 levels, highlighting inflammatory pathways as therapeutic targets.
In a randomized phase 2 trial, the anti‑LOX‑1 antibody MEDI6570 lowered circulating sLOX‑1 and IL‑6 but failed to reduce noncalcified coronary plaque volume versus placebo in post‑MI patients with residual inflammation.
In a large prospective cohort, obese BMI (≥30) was associated with worse post-concussion neurocognitive outcomes and a persistently proinflammatory blood biomarker profile, despite fewer baseline symptoms. Findings suggest obesity modifies
This study reveals multiple distinct molecular mechanisms, including epithelial and macrophage pathways, that contribute to residual asthma exacerbations in children treated with mepolizumab, highlighting the complexity of airway inflammati
This review explores how gut microbiota disturbances, especially L. reuteri and its metabolite ILA, influence post-TACE liver injury and prognosis in HCC patients, highlighting potential microbiota-targeted therapies.
This study explores how biological sex influences CRS diagnosis and inflammatory biomarkers, revealing sex-specific patterns that could inform personalized treatment.
An updated meta-analysis evaluates the effects of 0.5 mg colchicine on clinical outcomes after acute myocardial infarction, showing reduced hospital readmission but increased diarrhea risk without significant impact on major cardiovascular
New research links poor sleep quality in middle-aged and older adults to accelerated brain aging, with inflammation playing a key role. Improving sleep may help slow cognitive decline and promote brain health.
A 16-week Mediterranean diet intervention significantly reduced psoriasis severity and improved metabolic markers in patients with mild to moderate disease, suggesting diet’s role as adjunctive therapy in psoriasis management.
A causal analysis of nine dietary patterns reveals the Mediterranean diet as most effective in reducing all-cause and cardiovascular mortality, primarily through modulation of inflammatory biomarkers such as CRP, NPR, and SII.
A 16-week randomized trial demonstrates that daily hydroxytyrosol supplementation significantly reduces oxidative stress and inflammatory markers in overweight individuals with prediabetes, highlighting its potential in preventing aging-rel
This study evaluated the antidepressant effects of a Lactobacillus probiotic in overweight depressed patients with systemic low-grade inflammation, revealing no overall benefit but highlighting fecal formic acid as a potential biomarker for
Afternoon high-intensity interval exercise improves post-exercise blood glucose and reduces inflammation more effectively than morning sessions in type 2 diabetes, highlighting circadian influences on exercise metabolism and benefits of mea
New research reveals that common oral bacteria, particularly Viridans streptococci, can infiltrate arterial plaques, increasing the risk of heart attacks by triggering inflammation and plaque rupture.
A randomized clinical trial reveals older adults with insomnia have heightened depressive responses to inflammatory challenge, underscoring the need for targeted depression monitoring and prevention strategies in this vulnerable population.
Excessive iron supplementation accelerates phenotypic aging via inflammation, but anti-inflammatory and antioxidant diets may mitigate this risk, highlighting the importance of balanced iron intake and dietary patterns in aging health.
A groundbreaking discovery reveals a natural anti-inflammatory molecule in the body, homocysitaconate, whose levels can be boosted by vitamin B3 supplementation, offering new hope for managing severe inflammatory diseases.