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Evaluating Antidepressant Impact on Bipolar Depression: Insights from a Propensity Score Analysis in the STEP-BD Cohort
newsantidepressantsBipolar Depression

Evaluating Antidepressant Impact on Bipolar Depression: Insights from a Propensity Score Analysis in the STEP-BD Cohort

By MedXY|Oct 27, 2025

A propensity score analysis of STEP-BD data reveals no significant association between antidepressant use and either manic switch risk or symptomatic remission in bipolar depression, highlighting the need for alternative treatment strategie

Evaluating Pramipexole as Adjunct Therapy in Treatment-Resistant Bipolar Depression: Insights from the PAX-BD Trial
newsBipolar DepressionPramipexole

Evaluating Pramipexole as Adjunct Therapy in Treatment-Resistant Bipolar Depression: Insights from the PAX-BD Trial

By MedXY|Oct 24, 2025

The PAX-BD trial assessed pramipexole addition to mood stabilisers in treatment-resistant bipolar depression, revealing some mood and psychosocial benefits but no significant primary outcome improvement, highlighting the need for further re

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