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A study shows that reflux-related sulfide loss rewires esophageal redox proteins, increases PGE2 signaling, and helps drive Barrett’s esophagus, revealing a new potential therapeutic target.
A multicenter study demonstrates that prioritizing endoscopic submucosal dissection (ESD) for Barrett’s cancers >15mm significantly improves R0 resection rates and survival, particularly in T1b disease, compared to traditional endoscopic
This study reveals that elevated reflux secondary bile acids in Barrett’s esophagus influence the esophageal microbiome and gene expression, highlighting potential mechanisms underpinning progression to esophageal adenocarcinoma.