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History of Thrombosis and Hematologic Disease Double the Risk of New Clots in Persistently aPL‑Positive Patients: Prospective APS ACTION Registry Analysis
newsantiphospholipid syndrome

History of Thrombosis and Hematologic Disease Double the Risk of New Clots in Persistently aPL‑Positive Patients: Prospective APS ACTION Registry Analysis

By MedXY|Dec 5, 2025

In 1,067 persistently antiphospholipid antibody–positive patients followed for 4,727 person‑years, prior thrombosis and coexistent hematologic disease each conferred ~2‑fold increased risk for new thrombosis; microvascular disease and obesi

EAPSDAS: The First EULAR Disease Activity Score for Antiphospholipid Syndrome — What Clinicians Need to Know
newsantiphospholipid syndrome

EAPSDAS: The First EULAR Disease Activity Score for Antiphospholipid Syndrome — What Clinicians Need to Know

By MedXY|Dec 4, 2025

EULAR’s new antiphospholipid syndrome disease activity score (EAPSDAS) provides the first standardized, validated tool to measure APS activity across thrombotic, microvascular and obstetric manifestations — a major advance for clinical care

High Cardiovascular Risk but Poor Risk-factor Control in Antiphospholipid Syndrome — Worse in Primary APS than SLE-related APS
Cardiologyantiphospholipid syndromecardiovascular risk

High Cardiovascular Risk but Poor Risk-factor Control in Antiphospholipid Syndrome — Worse in Primary APS than SLE-related APS

By MedXY|Nov 30, 2025

A multinational cross-sectional study of 1003 people with antiphospholipid syndrome (APS) found high prevalence of hypertension, hyperlipidaemia, obesity and smoking, with suboptimal attainment of guideline targets — particularly among thos

Certolizumab Pegol Shows Promise in Reducing Adverse Pregnancy Outcomes in High-Risk APS Patients: Insights from the IMPACT Trial
Clinical Updatesadverse pregnancy outcomesantiphospholipid syndrome

Certolizumab Pegol Shows Promise in Reducing Adverse Pregnancy Outcomes in High-Risk APS Patients: Insights from the IMPACT Trial

By MedXY|Oct 8, 2025

The IMPACT trial demonstrates that adding certolizumab pegol to standard therapy reduces placenta-mediated adverse pregnancy outcomes in women with antiphospholipid syndrome and lupus anticoagulant, with favorable safety and neonatal outcom

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