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An expert consensus from the BPD Collaborative outlines pragmatic, lifespan-focused recommendations to identify, monitor, and manage prematurity-associated lung disease (PLD) and to standardize outpatient care from infancy through adulthood
Emerging evidence reveals gut microbiota profiles correlate with disease severity and survival in idiopathic pulmonary fibrosis, highlighting potential microbial biomarkers and treatment modifiers.
Age-adjusted WGS-estimated telomere length improves identification of pathologically short telomeres and detection of telomere-related variants in IPF, associating with survival outcomes but offering limited survival prediction beyond clini
This study investigates how dose reductions and discontinuations of antifibrotic therapies influence disease progression in idiopathic pulmonary fibrosis (IPF), revealing significant challenges in drug tolerability and the need for improved
A large retrospective study found that oral corticosteroids for ABPA in cystic fibrosis improve lung function, while adding antifungals offers no significant additional benefit in clinical outcomes.
Occupational exposure to both dust and fumes significantly increases the risk of future respiratory exacerbations, atherosclerotic cardiovascular disease, and pneumonia in smokers and former smokers, underscoring the need for targeted preve
This study compares the mechanical properties of slide tracheoplasty and end-to-end anastomosis in porcine tracheas, revealing lower tensile strength but greater force dispersion in slide tracheoplasty, with implications for airway reconstr
A phase 2 randomized trial shows that TISA-818, an anti-inflammatory montelukast-decapeptide conjugate, is safe and may improve respiratory outcomes in ARDS patients, especially non-intubated individuals, supporting larger trials.
This multicenter RCT demonstrates that contrast-enhanced ultrasound (CEUS)-guided biopsy surpasses conventional US- and CT-guided modalities in diagnostic yield, sensitivity, and safety for subpleural lung lesions, highlighting its clinical
Sputum eosinophilia is linked to increased asthma-specific health services use, while neutrophilic inflammation drives hospitalizations in COPD. Understanding these inflammatory patterns aids personalized management and resource planning.
A polygenic risk score (PRS) significantly associates with IPF diagnosis and mortality, demonstrating potential for improving clinical risk stratification using real-world biobank data.
A randomized trial shows that a 6-week corticosteroid taper is superior to a 3-week taper for mild immune-related pneumonitis, establishing 6 weeks as the evidence-based standard for short-term treatment success.
This study reveals mycophenolate and azathioprine do not improve 3-year transplant-free survival or lung function in fibrotic ILD, with potential harm in select subtypes. Robust randomized trials remain essential for guiding immunosuppressi
This review synthesizes evidence from the DCCT/EDIC study highlighting the high prevalence and risk factors of obstructive sleep apnea and poor sleep quality in older adults with long-standing type 1 diabetes, emphasizing the clinical and m
This study reveals that liver transplant recipients exhibit significantly reduced lung function and increased dyspnea compared to the general population, highlighting the need for heightened pulmonary surveillance in this vulnerable group.
A randomized controlled trial demonstrates that a multicomponent pulmonary rehabilitation program markedly improves ventilator weaning success and physiological recovery in patients aged 80 and older undergoing prolonged mechanical ventilat
This prospective Chinese cohort study found that airway mucus plugs on chest CT are linked to increased risk of exacerbations and COPD development, even in individuals with preserved spirometry, highlighting their prognostic value in early
Pulmonary artery dilation on chest CT correlates with pulmonary hypertension across chronic lung diseases, with diagnostic accuracy varying by disease subtype.
SPIROMICS study demonstrates that progression of CT-detected emphysema subtypes over one year independently predicts accelerated FEV₁ decline, offering valuable intermediate endpoints for COPD clinical trials.
Low arousal threshold (ArTH) in obstructive sleep apnea patients predicts progressive disengagement from hypoglossal nerve stimulation therapy, underscoring the importance of preoperative ArTH assessment for personalized adherence strategie
