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Among more than 26 million older U.S. adults, even PM2.5 levels below current standards were linked to higher hypertension hospitalization risk, suggesting no clearly safe low-exposure threshold.
Higher blood IL-6 levels were strongly linked to nine cardiovascular and mortality outcomes in nearly 60,000 adults, supporting IL-6 as an important inflammatory marker and potential prevention target.
A randomized trial found that medically tailored meals and fresh produce were highly feasible after HF hospitalization, but neither strategy improved the primary 90-day heart failure utilization outcome versus usual care.
Population-based testing for breast cancer pathogenic variants identified many women who would not have been flagged by clinical or polygenic risk models, supporting its role in risk-based screening.
A genome-first study found similar rates of pathogenic FH variants in African and European ancestry groups, but uncertain variants were more common and potentially more harmful in African ancestry individuals, highlighting the need for more
A large Tokyo case-crossover study found that short-term exposure to low ambient temperature increases acute heart failure admissions, especially in older adults, while patients with hypotensive presentations may be more vulnerable to heat.
A nationwide Medicare study found that women made up a declining share of TAVI patients, had more periprocedural complications, but slightly better long-term survival than men. The findings support sex-specific planning and follow-up in aor
A national Brazilian analysis found 3,480 maternal deaths were missed by official coding from 2010 to 2021, raising the median maternal mortality ratio from 58.2 to 67.5 per 100,000 live births.
A large Sweden-France analysis suggests rising MS prevalence is mainly survival-driven, increasing MND prevalence reflects growing incidence, and PD prevalence rises modestly through mixed demographic and survival effects.
In a large U.K. cohort, losing at least 15% of body weight within 2 years of type 2 diabetes diagnosis was linked to lower risks of heart, kidney, and eye complications, along with better glucose and blood pressure control.
This WISDOM Study analysis found that most women with breast cancer pathogenic variants would not have been flagged for high-risk screening by clinical or polygenic risk models alone, supporting population-based genetic testing.
A U.S. geospatial analysis found major state-level disparities in access to registered hand trauma centers, with 13.3% of the population outside a 6-hour catchment and 7.6% still uncovered at 12 hours.
A 2026 Annals commentary argues that boarding and crowding are enduring emergency department realities and that residency education should shift from avoidance to deliberate preparation for safe, effective practice in constrained systems.
An observational study in a Massachusetts FQHC network found that a telehealth navigator program with remote monitoring was associated with a substantial improvement in blood pressure control among Black adults with hypertension.
A historically grounded review of how physicians, librarians, publishers, and now algorithms have filtered the expanding medical literature, shaping what counts as visible, credible, and clinically actionable knowledge.
A multicenter German study shows pulmonary endoscopy produces substantial waste, much of it in procedure rooms, and suggests reusable gowns, procedural bundling, and recycling as practical ways to lower environmental impact.
A transportability analysis suggests the benefits seen in COAPT would likely persist in real-world U.S. patients with secondary mitral regurgitation if COAPT-style care, including optimized medical therapy, were delivered.
A large US claims-based cohort suggests that most open-angle glaucoma suspects have modest annual conversion risk after the first year, and that age- and treatment-informed surveillance intervals may help tailor follow-up intensity.
A multicenter prospective cohort study suggests that substantial surgeon social jet lag, but not midsleep variability alone, is associated with higher 30-day major adverse event risk after surgery and correlates with surgeon burnout.
In a large prospective U.S. cohort, severe maternal morbidity did not reduce breastfeeding initiation, but it was associated with lower odds of breastfeeding beyond 6 months and of exclusive breastfeeding.
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