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This study reveals the heterogeneous genetic architecture of impulsivity, uncovering diverse biological pathways linking it to neurodevelopment and psychopathology across the lifespan.
A multicenter randomized trial comparing seven antipsychotics in acute schizophrenia shows olanzapine and risperidone outperform several agents in efficacy but differ markedly in side effects, clarifying treatment choices.
This study links diminished grip strength in early psychosis to altered resting-state brain connectivity within key networks, suggesting grip strength as a potential marker for neural integrity and overall well-being in psychotic disorders.
An emotion-focused parenting intervention improves prefrontal cortex activation during emotion regulation in adolescent girls with internalizing symptoms, correlating with reductions in maternal unsupportive socialization and adolescent anx
A propensity score analysis of STEP-BD data reveals no significant association between antidepressant use and either manic switch risk or symptomatic remission in bipolar depression, highlighting the need for alternative treatment strategie
This review evaluates recent evidence on plasma AD biomarkers, especially phosphorylated tau217 and amyloid PET, for predicting cognitive decline in unimpaired individuals, highlighting their potential and limitations.
Whole-brain functional connectivity patterns predict multidimensional treatment outcomes across internalizing psychopathologies and various therapies, highlighting neural network biomarkers for personalized psychiatric care.
This study analyzes the diagnosis and medication initiation of ADHD among children aged 3-5 across multiple US health systems, highlighting sociodemographic disparities and clinical practices.
A secondary analysis of the SUMMIT trial shows that brief behavioral activation therapy significantly reduces suicide ideation in perinatal women, regardless of clinician type or treatment modality, highlighting a scalable approach for suic
This study reveals region- and size-specific dendritic spine deficits in cortical layer 3 neurons of schizophrenia patients, highlighting differential synaptic disruptions across visual and prefrontal cortical areas underpinning cognitive d
Implementing gamification in mobile health psychotherapy markedly improves adherence and reduces depressive symptoms among older adults, offering a promising avenue to address mental health care needs in aging populations.
The PAX-BD trial assessed pramipexole addition to mood stabilisers in treatment-resistant bipolar depression, revealing some mood and psychosocial benefits but no significant primary outcome improvement, highlighting the need for further re
The KARMA-Dep 2 trial reveals that serial ketamine infusions do not significantly outperform midazolam in reducing depressive symptoms among inpatients receiving usual psychiatric care, challenging assumptions about ketamine’s long-term ant
This article explores the link between prenatal and early postnatal lead exposure and adult anxiety and depression, emphasizing critical exposure windows and long-term mental health implications.
This study applies machine learning and explainable AI to identify factors associated with chronic pain, psychological distress, and their co-occurrence in Norwegian young adults, highlighting the importance of integrated approaches for ear
This review synthesizes evidence linking long-term air pollution and road traffic noise exposure with antidepressant medication dispensing, highlighting sex-specific associations and implications for mental health prevention strategies.
This prospective study reveals that prolonged exposure to fine particulate matter (PM2.5) significantly elevates risks of depression and anxiety, disproportionately affecting Black populations due to systemic inequities. Findings call for t
This study reveals that long-term treatment with lithium or valproate significantly lowers suicide risks in bipolar disorder patients. Combining atypical antipsychotics with these mood stabilizers further reduces suicide incidence, offering
A comprehensive 50-state survey reveals widespread conspiratorial thinking among American adults linked to demographic factors and COVID-19 vaccine hesitancy, with implications for public health strategies.
The HISTORI trial demonstrates that semaglutide significantly improves glycemic control, reduces weight, and enhances physical quality of life in schizophrenia patients treated with second-generation antipsychotics, without worsening psychi
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