Section
This review synthesizes global evidence, including meta-analyses, showing that school feeding programs modestly improve math achievement, enrollment, and growth metrics in socioeconomically disadvantaged children, with limited effects on re
Large Finnish and Swedish registry cohorts show clozapine is associated with lower psychiatric hospitalisation across schizophrenia-spectrum, bipolar disorder and severe depression without increased overall mortality or hospitalisation.
Three multinational phase 3 trials found no clinically meaningful cognitive benefit of the GlyT1 inhibitor iclepertin versus placebo in schizophrenia, though the drug was well tolerated. Results highlight methodological and biological chall
A living systematic review of 30 RCTs (n=1,480) finds moderate-to-large symptom reductions for MDMA in PTSD and serotonergic psychedelics in major depression and anxiety, but high risk of bias and low certainty overall; pragmatic, longer, a
A Finnish registry cohort (n=913,149) found that exposure to same-grade schoolmates’ self-harm modestly increased later self-harm risk (HR 1.05), with the largest effect around age 16 (HR ~1.45), suggesting time-limited social transmi
A multinational time-series analysis of 11.4 million admissions found that higher neighbourhood greenness (NDVI) was linked to lower hospital admissions for mental disorders overall, with heterogeneity across countries and disorder types an
A 1,565‑participant pragmatic randomized trial shows metformin added to lifestyle counseling produced modest but statistically significant reductions in BMI Z-score at 6 and 24 months in overweight/obese children and adolescents with bipola
A large, pragmatic randomized trial found that adjunctive metformin produced a modest but statistically significant reduction in BMI Z-score at 6 and 24 months among overweight and obese youth with bipolar spectrum disorders treated with se
A longitudinal, nationally representative cohort study found that within-person transition from current to former cigarette smoking was associated with a 30–43% higher odds of sustained recovery from other substance use disorders, supportin
A pragmatic cluster randomized trial found that adding OUD-specific components to collaborative care in primary care clinics reduced days of opioid use more than collaborative care for mental health alone, without clear additional mental he
In ENLIGHTEN, a biomarker-guided randomized trial, ANK3-positive patients with treatment‑resistant depression randomized to liafensine achieved larger MADRS improvements than placebo (mean difference −4.4; 95% CI −7.6 to −1.3; P = .006), wi
A randomized trial in adults with moderate–severe cannabis use disorder found 12 weeks of supervised HIIT did not improve a composite MRI measure of hippocampal integrity versus strength/resistance training; exercise participation was feasi
A 2‑arm randomized trial (MSPIRE) found brief cognitive behavioral therapy (BCBT) significantly reduced suicide attempts versus present‑centered therapy in suicidal military personnel and veterans, despite comparable reductions in suicidal
A large Danish register and genetic study shows overlapping but distinct environmental and genetic risk factors for nonfatal suicide attempts and death by suicide, with chronic and functional health problems linked more to attempts and seve
A double‑blind RCT in 160 healthy adults found that intranasal oxytocin combined with structured positive interaction and daily physical intimacy (affectionate touch, sex) was associated with reduced cortisol and modestly faster dermatologi
A prospective Danish cohort found that adults reporting lifetime sexual assault had substantially higher 5‑year incidence of functional somatic disorders—especially multiorgan FSD and chronic widespread pain—after adjustment for psychosocia
Sleep disorders and depression are common in people living with HIV. Modafinil may improve daytime sleepiness, fatigue and cognition—especially for OSA-related EDS or augmentation in depression—but HIV-specific RCT data and ART interaction
Sleep disturbances and mood disorders profoundly affect people living with HIV. Modafinil emerges as a promising therapy addressing daytime sleepiness, depression, and cognitive challenges, improving quality of life.
A 151‑trial network meta‑analysis of 58,534 participants shows marked differences among 30 antidepressants in weight, blood pressure, heart rate, lipids, glucose and liver enzymes; findings support individualized choice and targeted baselin
A 2023 population survey of 4,002 adults in the UK and US found that positive screens for avoidant/restrictive food intake disorder (ARFID) were common among people with disorders of gut–brain interaction (DGBI) and associated with greater
