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Azetukalner, a KV7 potassium channel opener, demonstrated clinically meaningful antidepressant effects and significant improvement in anhedonia in adults with major depressive disorder in a 6-week randomized trial, supporting further develo
A phase 2b trial reveals that single doses of MM120 produce dose-dependent reductions in anxiety symptoms in adults with moderate to severe generalized anxiety disorder, paving the way for phase 3 studies.
Amygdala tau accumulation in cognitively normal older adults correlates with worsening depressive symptoms, especially in APOE ε4 carriers, highlighting its role in neuropsychiatric changes during aging.
A comprehensive study spanning 47 countries reveals changing suicide mortality rates among adults aged 65+, highlighting method-specific risks and projecting future trends amid global population ageing.
A cluster randomised controlled trial demonstrates that the Conversations about Suicide course delivered in Australian Men’s Sheds significantly improves recommended suicide prevention actions among older men, with sustained effects a
This study highlights how poor mental well-being during adolescence predicts increased risks of mental illness, risky behaviors, and mortality in young adulthood, emphasizing the urgency for early identification and intervention.
This study compares long-acting injectable to oral antipsychotics in older schizophrenia patients, highlighting benefits in relapse prevention and mortality reduction, with specific considerations for adverse effects.
This study finds no significant benefit of the Circle of Security-Parenting intervention added to usual care for improving mental health and bonding among new parents in NHS settings.
A nationwide study in Spain from 2018 to 2023 reveals increasing rates of non-lethal intentional self-harm and suicide, particularly among young women, underscoring the need for targeted mental health interventions.
This comprehensive review examines the recent Finnish study highlighting the complex relationship between hyperemesis gravidarum and depression, emphasizing clinical implications for integrated mental health screening during reproductive ca
A pragmatic trial comparing SSRIs and written exposure therapy in primary care PTSD treatment found similar effectiveness initially; switching to SNRI was superior to WET augmentation for SSRI nonresponders.
Stimulant use disorder diagnoses in young adult Medicaid enrollees have markedly increased from 2001 to 2020, especially for noncocaine psychostimulants, highlighting an urgent need for targeted interventions and evidence-based treatments a
This systematic review evaluates lithium’s efficacy in reducing suicidal ideation, attempts, and completed suicide, highlighting methodological challenges and the likelihood of benefit despite lack of statistical significance in RCTs.
This article examines prognostic factors predicting seizure recurrence after a first unprovoked seizure in children and adults, highlighting the roles of EEG abnormalities, brain imaging, nocturnal seizures, and family history, while addres
This meta-analysis examines dropout rates in digital psychosocial interventions for adult illicit drug users, identifying key demographic, clinical, and intervention-related factors associated with treatment adherence.
Aerobic exercise significantly alleviates depressive symptoms in children and adolescents, especially in diagnosed adolescents, with 590 METs-min/week at moderate intensity identified as the optimal dose.
This meta-analysis examines Coenzyme Q10 supplementation’s impact on depression and anxiety, revealing modest benefits for depression at low doses and short durations but insufficient evidence for anxiety improvement.
This review evaluates brexpiprazole’s efficacy and safety for agitation in Alzheimer’s disease, revealing modest symptom improvement but uncertain safety profiles, underscoring the need for individualized therapy and further res
A systematic synthesis of clinical practice guideline recommendations for preventing and managing mental disorders after traumatic injury, with prioritized, implementable actions for acute and early recovery care.
Delayed cannabis test results in children under 6 with poisoning symptoms prolong ED visits and influence neuroimaging use. Faster toxicology screening could optimize care and reduce unnecessary scans.
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