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A comprehensive evaluation of nearly five years of esketamine nasal spray use confirms its safety profile consistent with clinical trials, with no new safety signals detected in over 1.4 million treatment sessions.
This longitudinal study reveals distinct trajectories of depressive symptoms among Chinese adolescents, highlighting key sociodemographic and behavioral predictors that can inform early intervention strategies.
A multi-site fMRI study demonstrates that effective connectivity patterns between the cerebellum and fronto-temporal areas accurately classify major depressive disorder with over 94% accuracy, offering a promising neuroimaging biomarker to
This study clarifies how estradiol and progesterone differentially affect symptoms in PMDD, confirming symptom remission during ovarian suppression and distinct hormonal triggers in affected women versus healthy controls.
This study identifies reduced neural efficiency during threat processing as a biomarker in pediatric anxiety disorders, linked to diagnosis and poorer CBT outcomes, offering potential for patient stratification and novel intervention target
An international expert consensus offers standardized, operational criteria for defining relapse in schizophrenia to reduce study heterogeneity, improve research comparability, and guide clinical reporting.
This study reveals the heterogeneous genetic architecture of impulsivity, uncovering diverse biological pathways linking it to neurodevelopment and psychopathology across the lifespan.
A multicenter randomized trial comparing seven antipsychotics in acute schizophrenia shows olanzapine and risperidone outperform several agents in efficacy but differ markedly in side effects, clarifying treatment choices.
This study links diminished grip strength in early psychosis to altered resting-state brain connectivity within key networks, suggesting grip strength as a potential marker for neural integrity and overall well-being in psychotic disorders.
An emotion-focused parenting intervention improves prefrontal cortex activation during emotion regulation in adolescent girls with internalizing symptoms, correlating with reductions in maternal unsupportive socialization and adolescent anx
A propensity score analysis of STEP-BD data reveals no significant association between antidepressant use and either manic switch risk or symptomatic remission in bipolar depression, highlighting the need for alternative treatment strategie
This review evaluates recent evidence on plasma AD biomarkers, especially phosphorylated tau217 and amyloid PET, for predicting cognitive decline in unimpaired individuals, highlighting their potential and limitations.
Whole-brain functional connectivity patterns predict multidimensional treatment outcomes across internalizing psychopathologies and various therapies, highlighting neural network biomarkers for personalized psychiatric care.
This study analyzes the diagnosis and medication initiation of ADHD among children aged 3-5 across multiple US health systems, highlighting sociodemographic disparities and clinical practices.
A secondary analysis of the SUMMIT trial shows that brief behavioral activation therapy significantly reduces suicide ideation in perinatal women, regardless of clinician type or treatment modality, highlighting a scalable approach for suic
This study reveals region- and size-specific dendritic spine deficits in cortical layer 3 neurons of schizophrenia patients, highlighting differential synaptic disruptions across visual and prefrontal cortical areas underpinning cognitive d
Implementing gamification in mobile health psychotherapy markedly improves adherence and reduces depressive symptoms among older adults, offering a promising avenue to address mental health care needs in aging populations.
The PAX-BD trial assessed pramipexole addition to mood stabilisers in treatment-resistant bipolar depression, revealing some mood and psychosocial benefits but no significant primary outcome improvement, highlighting the need for further re
The KARMA-Dep 2 trial reveals that serial ketamine infusions do not significantly outperform midazolam in reducing depressive symptoms among inpatients receiving usual psychiatric care, challenging assumptions about ketamine’s long-term ant
This article explores the link between prenatal and early postnatal lead exposure and adult anxiety and depression, emphasizing critical exposure windows and long-term mental health implications.
