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Highlights Background Dementia and depression are intertwined public health crises, together accounting for a substantial...
A randomized clinical trial demonstrates that telehealth-delivered music therapy is noninferior to cognitive behavioral therapy for reducing anxiety in cancer survivors, providing durable, clinically meaningful improvements and a viable alt
A population-based study reveals that nearly one-quarter of TIA patients experience depression, which significantly increases the risk of mortality and disability, regardless of whether acute ischemic lesions are present on imaging.
A large-scale nationwide study reveals that individuals with atherosclerotic cardiovascular disease (ASCVD), including myocardial infarction and stroke, face a 43% higher risk of suicide. The risk nearly doubles for those suffering from bot
This large-scale study of 35,751 children characterizes ARFI phenotypes, revealing a 6.3% clinical prevalence and significant genetic heritability. Findings link ARFI to the ADCY3 locus and long-term neurodevelopmental difficulties, emphasi
A large-scale cohort study demonstrates that while hormonal contraceptives are generally associated with lower cardiovascular risk in women, this protective effect is lost in those with PTSD, highlighting a critical intersection between psy
A multi-center randomized clinical trial involving 257 youths found that adjunctive omega-3 fatty acids (1.5 g/d) did not outperform placebo in treating moderate-to-severe pediatric major depressive disorder, despite high adherence and conc
A randomized clinical trial demonstrates that smartphone-based ecological momentary assessment (EMA) is significantly more sensitive than retrospective questionnaires in detecting the daytime clinical benefits of suvorexant, particularly re
A prospective study reveals that patients with mental health conditions face significant delays in STEMI diagnosis, resulting in larger infarct sizes and a twofold increase in five-year cardiovascular mortality compared to those without suc
Experts have released the VasCog-2-WSO criteria, an updated international standard for diagnosing vascular cognitive impairment and dementia. This revision introduces a preclinical stage and incorporates modern neuroimaging and fluid biomar
The CLARO randomized clinical trial investigated whether a collaborative care model could improve outcomes for patients with opioid use disorder and co-occurring depression or PTSD. The study found no statistically significant advantages ov
A multicenter trial finds low-dose amitriptyline non-inferior to CBT-I for comorbid insomnia based on a liberal margin. However, CBT-I yielded superior clinical response rates and fewer side effects, reinforcing its status as the gold-stand
A randomized trial comparing Tai Chi and CBT-I in adults over 50 found that while CBT-I offers faster relief, Tai Chi achieves non-inferior results at 12 months post-intervention, suggesting it is a viable long-term strategy for insomnia ma
A comprehensive BMJ umbrella review synthesizes evidence for ADHD interventions across the lifespan, confirming the efficacy of stimulants and non-stimulants in the short term while revealing a critical lack of high-certainty long-term data
A cluster-randomized trial of the ‘OurFutures Mental Health’ program demonstrates significant short-term reductions in anxiety symptoms among Year 8 and 9 students, highlighting the potential for scalable, digital, trauma-inform
A large, rigorous study found that sertraline, an antidepressant, does not significantly lower the risk of repeated violent crimes among impulsive offenders.
The SOMA.GUT-RCT investigated a targeted psychological intervention for IBS and UC. While the primary 3-month endpoint showed no significant symptom reduction compared to standard care, exploratory data revealed significant psychological im
This multicenter longitudinal study reveals that delusional memories, rather than simple amnesia, are the primary predictors of persistent PTSD symptoms following critical illness, highlighting the critical roles of delirium and sedation in
A large-scale cohort study emulating randomized trials indicates that benzodiazepine use during pregnancy significantly increases the risk of abortion and preterm birth, even after accounting for competing risks and maternal factors. Risks
The VALAD randomized clinical trial found that valacyclovir did not improve outcomes in patients with early symptomatic Alzheimer’s and HSV seropositivity. Instead, patients receiving the antiviral showed significantly greater cognitive dec
