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SPeCIFY: Practical Guidance for Inducing and Measuring Mental Fatigue in Movement Science
newsMental Fatigue

SPeCIFY: Practical Guidance for Inducing and Measuring Mental Fatigue in Movement Science

By MedXY|Nov 4, 2025

Clear, pragmatic recommendations to standardize how mental fatigue is induced, measured and reported in movement-science studies—centered on the SPeCIFY reporting checklist and multi-method assessment.

Group-Based Interventions to Reduce Gambling Involvement Among Male Football Fans
newsgroup-based therapypublic health

Group-Based Interventions to Reduce Gambling Involvement Among Male Football Fans

By MedXY|Nov 2, 2025

This case report summarizes the feasibility study of a group-based gambling prevention intervention among male football fans, revealing recruitment challenges and insights into intervention delivery within football club contexts.

Understanding Sex- and Age-Specific Suicide Risk Indicators: Insights from a Large Swedish Case-Control Study
newsage differencesepidemiology

Understanding Sex- and Age-Specific Suicide Risk Indicators: Insights from a Large Swedish Case-Control Study

By MedXY|Oct 31, 2025

This Swedish population-based study highlights how suicide risk indicators vary by sex and age, showing males and older adults exhibit fewer, but often higher absolute risk indicators, underscoring the need for tailored suicide prevention s

Systemic Inflammation as a Modulator of Anhedonia in Major Depressive Disorder: Insights from an LPS Challenge Trial
newsAnhedoniamajor depressive disorder

Systemic Inflammation as a Modulator of Anhedonia in Major Depressive Disorder: Insights from an LPS Challenge Trial

By MedXY|Oct 31, 2025

This RCT reveals that adults with major depressive disorder and elevated systemic inflammation exhibit heightened anhedonic responses to an inflammatory challenge, highlighting inflammation’s role in depression symptomatology.

Unraveling Genetic Links Between Problematic Alcohol Use and Psychiatric Disorders: Insights from Large-Scale Genomic Analyses
Internal MedicineGWASpsychiatric disorders

Unraveling Genetic Links Between Problematic Alcohol Use and Psychiatric Disorders: Insights from Large-Scale Genomic Analyses

By MedXY|Oct 30, 2025

This study reveals significant shared genetic architectures between problematic alcohol use and various psychiatric disorders, identifying key genes like TTC12 and ANKK1 that may underlie their comorbidity.

Cognitive Control Deficits in Specific Problematic Internet Uses: Insights From Clinically Validated Neurocognitive Assessments
Neurologycognitive impairmentExecutive Function

Cognitive Control Deficits in Specific Problematic Internet Uses: Insights From Clinically Validated Neurocognitive Assessments

By MedXY|Oct 30, 2025

This study reveals distinct impairments in executive functions and inhibitory control across types of problematic internet use, highlighting the need for tailored interventions to address self-control deficits in internet addiction.

Polygenic Influences and Anticholinergic Burden: Unraveling Their Joint Impact on Cognition and Brain Structure in Psychosis Spectrum Disorders
Neurologybrain structurecognition

Polygenic Influences and Anticholinergic Burden: Unraveling Their Joint Impact on Cognition and Brain Structure in Psychosis Spectrum Disorders

By MedXY|Oct 30, 2025

This study reveals that genetic predispositions interact with anticholinergic medication burden to influence cognitive deficits and brain gray matter volume reductions in psychosis spectrum disorders, offering new insights into personalized

Cognition-Guided EEG Neurofeedback Enhances Response Inhibition in Methamphetamine Use Disorder: A Promising Neuromodulation Approach
NeurologyEEGMethamphetamine Use Disorder

Cognition-Guided EEG Neurofeedback Enhances Response Inhibition in Methamphetamine Use Disorder: A Promising Neuromodulation Approach

By MedXY|Oct 30, 2025

Cognition-guided EEG neurofeedback targeting methamphetamine cue-related brain activity significantly improves response inhibition in men with methamphetamine use disorder, surpassing standard rehabilitation outcomes and offering a novel in

Telehealth Prescribing of ADHD Stimulants: Assessing Risks for Subsequent Substance Use Disorders
newsADHDStimulant Use Disorder

Telehealth Prescribing of ADHD Stimulants: Assessing Risks for Subsequent Substance Use Disorders

By MedXY|Oct 30, 2025

This study evaluates whether initiating ADHD stimulant prescriptions via telehealth affects later risks of stimulant or other substance use disorders, finding no SUD risk increase but a potential rise in stimulant use disorder risk.

Unveiling the Impact of Copy Number Variants on Child Psychopathology and Cognitive Development: Insights from the ABCD Study
newscognitive developmentcopy number variants

Unveiling the Impact of Copy Number Variants on Child Psychopathology and Cognitive Development: Insights from the ABCD Study

By MedXY|Oct 30, 2025

This study elucidates how copy number variants (CNVs) contribute to variability in child psychopathology and cognitive function, highlighting specific CNV regions and aggregated genetic risk affecting attention and cognitive domains during

Treatment Retention in Opioid Use Disorder During Pregnancy: Buprenorphine vs Methadone Discontinuation Patterns
newsbuprenorphinemethadone

Treatment Retention in Opioid Use Disorder During Pregnancy: Buprenorphine vs Methadone Discontinuation Patterns

By MedXY|Oct 30, 2025

This nationwide cohort study reveals higher discontinuation rates of buprenorphine than methadone during pregnancy and up to one year postpartum, highlighting significant challenges in treatment retention for opioid use disorder in pregnant

Reduced Brain Iron Linked to Striatal Hyperdopaminergia in Schizophrenia: Insights from QSM MRI and PET Imaging
Neurologybrain ironquantitative susceptibility mapping

Reduced Brain Iron Linked to Striatal Hyperdopaminergia in Schizophrenia: Insights from QSM MRI and PET Imaging

By MedXY|Oct 30, 2025

This study reveals that lower brain iron levels in the substantia nigra-ventral tegmental area are associated with elevated striatal dopamine synthesis in schizophrenia, highlighting a potential new target for therapeutic intervention.

Neighborhood Social Vulnerability and Racial Disparities in Schizophrenia Spectrum Disorder Prevalence: Insights from a National US Study
newsracial disparitiesstructural racism

Neighborhood Social Vulnerability and Racial Disparities in Schizophrenia Spectrum Disorder Prevalence: Insights from a National US Study

By MedXY|Oct 30, 2025

This national study reveals significant ethnoracial disparities in schizophrenia spectrum disorders prevalence linked to neighborhood social vulnerability, highlighting structural racism’s role in mental health inequities among non-Hi

Unveiling the Iron-Dopamine Link in Schizophrenia: Insights from QSM MRI and PET Imaging
newsbrain ironquantitative susceptibility mapping

Unveiling the Iron-Dopamine Link in Schizophrenia: Insights from QSM MRI and PET Imaging

By MedXY|Oct 30, 2025

This study reveals reduced brain iron in the substantia nigra-ventral tegmental area correlating with increased striatal dopamine synthesis in schizophrenia, suggesting novel neurobiological mechanisms and potential therapeutic targets.

Assessing Nearly Five Years of Real-World Safety Data on Esketamine Nasal Spray in the United States
newsdepressionesketamine

Assessing Nearly Five Years of Real-World Safety Data on Esketamine Nasal Spray in the United States

By MedXY|Oct 30, 2025

A comprehensive evaluation of nearly five years of esketamine nasal spray use confirms its safety profile consistent with clinical trials, with no new safety signals detected in over 1.4 million treatment sessions.

Unraveling Depressive Symptom Trajectories in Early Adolescents: Insights from a 12-Month Cohort in Nanchong, China
newsadolescencedepressive symptoms

Unraveling Depressive Symptom Trajectories in Early Adolescents: Insights from a 12-Month Cohort in Nanchong, China

By MedXY|Oct 30, 2025

This longitudinal study reveals distinct trajectories of depressive symptoms among Chinese adolescents, highlighting key sociodemographic and behavioral predictors that can inform early intervention strategies.

Harnessing Effective Connectivity Between Cerebellum and Fronto-Temporal Regions for Objective Major Depressive Disorder Diagnosis: Insights From a Multi-Site fMRI Study
NeurologyfMRImajor depressive disorder

Harnessing Effective Connectivity Between Cerebellum and Fronto-Temporal Regions for Objective Major Depressive Disorder Diagnosis: Insights From a Multi-Site fMRI Study

By MedXY|Oct 30, 2025

A multi-site fMRI study demonstrates that effective connectivity patterns between the cerebellum and fronto-temporal areas accurately classify major depressive disorder with over 94% accuracy, offering a promising neuroimaging biomarker to

Unraveling Ovarian Steroid Impacts in PMDD: Insights from Expanded Hormone Addback Study
newsestradiolprogesterone

Unraveling Ovarian Steroid Impacts in PMDD: Insights from Expanded Hormone Addback Study

By MedXY|Oct 30, 2025

This study clarifies how estradiol and progesterone differentially affect symptoms in PMDD, confirming symptom remission during ovarian suppression and distinct hormonal triggers in affected women versus healthy controls.

Reduced Threat-Related Neural Efficiency as a Biomarker for Pediatric Anxiety: Implications for Diagnosis and CBT Response
newsbiomarkersCognitive Behavioral Therapy

Reduced Threat-Related Neural Efficiency as a Biomarker for Pediatric Anxiety: Implications for Diagnosis and CBT Response

By MedXY|Oct 30, 2025

This study identifies reduced neural efficiency during threat processing as a biomarker in pediatric anxiety disorders, linked to diagnosis and poorer CBT outcomes, offering potential for patient stratification and novel intervention target

Defining Relapse in Schizophrenia: New International Consensus to Standardize Research and Care
newsConsensusrelapse

Defining Relapse in Schizophrenia: New International Consensus to Standardize Research and Care

By MedXY|Oct 30, 2025

An international expert consensus offers standardized, operational criteria for defining relapse in schizophrenia to reduce study heterogeneity, improve research comparability, and guide clinical reporting.

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