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The VALAD randomized clinical trial found that valacyclovir did not improve outcomes in patients with early symptomatic Alzheimer’s and HSV seropositivity. Instead, patients receiving the antiviral showed significantly greater cognitive dec
A pooled analysis of over 11,000 patients from the INTERACT trials demonstrates that intensive blood pressure reduction significantly improves functional recovery in acute intracerebral hemorrhage, with the most robust benefits observed whe
A large-scale longitudinal study reveals that α-synuclein seed amplification assay (SAA) kinetic measures, particularly time to threshold, can differentiate Parkinson’s from PSP and predict future cognitive decline independently of Al
A pivotal longitudinal study demonstrates that plasma p-tau217 and GFAP accurately predict amyloid-β and tau deposition, cognitive decline, and dementia risk in adults with Down syndrome, offering a transformative, non-invasive tool for cli
The Walk ‘n Watch trial shows that a structured, progressive walking protocol significantly improves endurance in subacute stroke patients, providing a 43.6-meter advantage over usual care without increasing serious adverse events.
The Phase 2 FENopta trial demonstrates that fenebrutinib, a highly selective, reversible BTK inhibitor, significantly reduces MRI disease activity by 69% in relapsing multiple sclerosis while maintaining a favorable safety profile over 48 w
Case series reports acute axonal neuropathy post-infection in children with biallelic RCC1 variants, often misdiagnosed as Guillain-Barré syndrome, showing variable severity and highlighting impaired nucleocytoplasmic transport as pathogeni
The MSU-TELEMED trial demonstrates that a telemedicine model for mobile stroke units significantly improves neurologist resource utilization while maintaining safety, outperforming the traditional onboard neurologist model in a hierarchical
A Phase 2 triple-blind trial confirms that 16 mg of candesartan daily significantly reduces monthly migraine days compared to placebo, offering a well-tolerated oral alternative for patients with episodic migraine.
This case-control study identifies altered slow-wave activity progression and increased respiratory variability during NREM sleep as significant biomarkers for SUDEP risk, providing a potential framework for objective clinical screening and
The MSU-TELEMED trial demonstrates that telemedicine models for Mobile Stroke Units are superior to onboard neurologist care. By dramatically improving physician resource utilization without compromising safety, telemedicine provides a more
A randomized clinical trial demonstrates that home-based gamma transcranial alternating current stimulation (tACS) over the precuneus safely improves cognitive outcomes and activities of daily living in patients with prodromal and mild Alzh
This article analyzes a nationwide decentralized RCT and a systematic meta-analysis to evaluate the efficacy of digital Cognitive Behavioral Therapy for Insomnia (CBT-I), highlighting its role as a scalable, evidence-based first-line treatm
This article explores how automated EEG background analysis via the Brain State of the Newborn (BSN) score provides objective, early-life prognostication for neonates with HIE, significantly improving the prediction of 2-year neurodevelopme
The AZA-PD phase 2 trial found that while azathioprine was well-tolerated in early Parkinson’s disease, it did not significantly improve gait-axial scores. However, exploratory data suggests potential motor benefits in female patients
The LAST-long randomized trial found that an 18-month coordinator-led multimodal intervention did not significantly prevent functional decline or dependency in patients with mild stroke compared to standard care, highlighting challenges in
A 15-year observational study of over 45,000 TBI patients reveals a significant increase in hospital mortality and a tripling of life-sustaining therapy withdrawal, alongside rising rates of hypoxaemia, raising urgent questions about ethica
A large-scale prospective study across England’s NHS reveals that AI imaging software significantly boosts endovascular thrombectomy rates for acute stroke patients. Implementation was associated with a 100% relative increase in treat
An international evaluation of the SEIZURE score reveals limited global predictive power for acute seizures in encephalitis. While the tool performs well in Western Europe, particularly Portugal, its utility elsewhere is hampered by etiolog
A multinational randomized trial found that adding high‑dose oral rifampin (total 35 mg/kg for 8 weeks) to standard therapy did not reduce 6‑month mortality in adults with tuberculous meningitis and was associated with more drug‑induced liv
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