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A study of 3,910 former college athletes found that a history of multiple concussions is significantly linked to worse mental health and sleep quality within five years of retirement, though most remain within normal clinical ranges.
A large-scale multicenter study reveals that persistent high-level Epstein-Barr nuclear antigen 1 (EBNA-1) peptide antibody titers serve as a highly specific biomarker, effectively distinguishing Multiple Sclerosis from other neuroinflammat
This review synthesizes findings from a national multicenter study identifying that hyperghrelinemia is a specific biomarker for Prader-Willi Syndrome, whereas other rare neurodevelopmental disorders exhibit normal ghrelin levels despite se
The BRAVO study provides critical evidence that while IV thrombolysis improves recovery in isolated vertebral artery occlusion, endovascular treatment may increase risks unless reserved for severe cases.
This review synthesizes recent evidence identifying PAICS downregulation as a critical link between C9orf72 loss-of-function, DNA repair failure, and cerebellar neurodegeneration, highlighting its potential as a therapeutic target.
A large-scale longitudinal study reveals that motor vehicle accidents cause significantly worse acute traumatic brain injury outcomes compared to falls. However, by one year post-injury, disability levels and community participation converg
This retrospective study identifies a high prevalence of spinal cord p-tau and protein copathologies in patients with Chronic Traumatic Encephalopathy (CTE), suggesting the existence of a ‘trauma-related encephalomyelopathy’ lin
This translational study demonstrates that the FKBP5 protein, a regulator of the stress response, significantly influences stroke outcomes. Lower FKBP5 levels correlate with smaller brain lesions in mice, while high-expression genetic varia
A prospective multicenter study reveals that the no-reflow phenomenon is a dynamic, evolving pathology following successful thrombectomy. It is significantly associated with infarct growth and poor functional outcomes, suggesting that achie
This review explores how paramagnetic rim lesions (PRLs), as markers of chronic active demyelination, serve as powerful predictors for clinical Multiple Sclerosis conversion in individuals with radiologically isolated syndrome.
This article synthesizes evidence from a large-scale individual participant data meta-analysis, demonstrating that early perihematomal edema growth (at 24 and 72 hours) is an independent predictor of death and disability after intracerebral
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A 2-year longitudinal study reveals that hip strength and walking speed are the most sensitive markers for progression in Late-Onset Pompe Disease, offering clinicians precise thresholds for meaningful intervention.
This review synthesizes evidence on the impact of kidney function, BMI, and anemia on plasma p-tau217 diagnostic accuracy, advocating for subgroup-specific cutoff strategies to improve clinical outcomes.
A large-scale multicenter study demonstrates that all subtypes of hemorrhagic transformation, including mild infractions, significantly impair functional recovery after stroke recanalization. Automated noncontrast CT biomarkers now offer su
This study highlights how comorbid Alzheimer’s and FTLD neuropathologies manifest through unique neuropsychiatric profiles, such as increased anxiety and personality changes, providing clinicians with vital clues for identifying mixed
A pivotal randomized clinical trial reveals that targeted training of the ipsilesional arm in chronic stroke patients with severe hemiparesis significantly improves motor speed and hand function, with benefits sustained for six months.
A Phase 3 pragmatic trial found that 12 hours of weekly intensive task-specific training added to usual care does not improve motor recovery in recent spinal cord injury patients, suggesting a potential plateau in the benefits of early reha
A 20-year follow-up study of 130 patients demonstrates that transcatheter PFO closure is highly effective in preventing recurrent strokes, though long-term antithrombotic therapy increases bleeding risks, particularly in women.
This review synthesizes evidence distinguishing perivascular space enlargement mechanisms in cerebral amyloid angiopathy (CAA) versus deep perforator arteriopathy (DPA), highlighting the diagnostic utility of CSF Aβ42/40 ratios in vascular
