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MedXY AI/MedXY News/Section: Emergency Medicine

Recombinant Factor VIIa Fails to Improve Functional Outcomes in Hyperacute Intracerebral Haemorrhage Despite Reduced Bleeding: Results from the FASTEST Trial

MedXY Editorial Team•Feb 17, 2026•Emergency Medicine
intracerebral haemorrhageneurocritical care

Highlights

  • Recombinant factor VIIa (rFVIIa) administered within 2 hours of symptom onset significantly reduced the expansion of both intracerebral haemorrhage (ICH) and intraventricular haemorrhage (IVH).
  • Despite the reduction in hematoma growth, there was no significant improvement in 180-day functional outcomes as measured by the modified Rankin Scale (mRS).
  • The trial was stopped early for futility following a planned interim analysis.
  • Treatment with rFVIIa was associated with a higher risk of life-threatening thromboembolic complications compared to placebo (5% vs 1%).

Background: The Challenge of Intracerebral Haemorrhage

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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