Introduction: Expanding the Boundaries of Chronic Traumatic Encephalopathy
The medical understanding of Chronic Traumatic Encephalopathy (CTE) has traditionally focused on the cerebral cortex, specifically the pathognomonic accumulation of hyperphosphorylated tau (p-tau) in neurons and astrocytes around small blood vessels at the depths of the cortical sulci. However, emerging clinical evidence suggests that individuals exposed to repetitive head impacts (RHI) often present with a constellation of symptoms that extend beyond cognitive and behavioral changes, frequently involving motor dysfunction reminiscent of amyotrophic lateral sclerosis (ALS) or parkinsonism. A groundbreaking study by Tanaka et al., published in JAMA Neurology (2026), provides critical evidence that the pathology of CTE is not confined to the brain but represents a systemic trauma-related encephalomyelopathy involving the spinal cord.
