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Researchers using human stem cell models have discovered that macrophages actively amplify the electrical signals of damaged nerves, driving the spontaneous pain characteristic of neuropathy, offering a new target for non-opioid pain relief
A large-scale prospective study identifies high basal ganglia perivascular space (BGPVS) burden as a significant predictor of both major bleeding and ischemic stroke in patients on antithrombotic regimens, offering a new imaging biomarker f
The Phase 3 TEMPO-3 trial demonstrates that tavapadon, a novel selective D1/D5 agonist, significantly improves daily ‘good-on-time’ and reduces ‘off-time’ in Parkinson’s disease patients with motor fluctuations, pres
A multicenter randomized controlled trial reveals that integrating action observation with virtual reality significantly improves paretic hand dexterity in stroke patients, with benefits persisting six months post-intervention, offering a s
A groundbreaking human iPSC-derived co-culture study reveals that macrophages respond to neuronal injury by adopting a pro-algesic state, directly intensifying spontaneous neuronal firing—a key driver of chronic neuropathic pain and a novel
A large prospective study reveals that a high burden of basal ganglia enlarged perivascular spaces (BGPVSs) significantly increases the risk of both ischemic stroke and major bleeding in patients on antithrombotic therapy, positioning BGPVS
The Phase 3 TEMPO-3 trial demonstrates that tavapadon, a selective D1/D5 agonist, significantly increases ‘good-on-time’ and reduces ‘off-time’ in Parkinson’s patients with motor fluctuations, offering a favorable sa
A landmark study using lesion network mapping reveals that cerebral palsy after neonatal stroke is driven by disruptions in extensive functional networks, including the thalamus and cerebellum, rather than just localized motor cortex damage
This review analyzes evidence that amygdala damage, while impairing emotional recognition accuracy, does not diminish the intrinsic motivation to engage empathically, challenging traditional neurological models of psychopathy.
A pooled analysis of 11,269 patients from the INTERACT and ATACH-II trials reveals that 24-hour systolic blood pressure trajectories, rather than just single targets, significantly influence functional outcomes after intracerebral hemorrhag
The SECRETO study demonstrates that infections within the preceding week increase the odds of cryptogenic ischemic stroke by 2.6-fold in young adults, primarily driven by transient increases in von Willebrand Factor and Factor VIII levels.
A multicenter study reveals that nearly one-quarter of patients meeting the newest multiple sclerosis criteria for optic neuritis actually have MOGAD or NMOSD, emphasizing the critical role of antibody screening and detailed orbital MRI in
The Phase 2b PARADIGM trial reveals that PrimeC, a novel oral combination therapy, is safe and significantly slows functional decline and reduces the risk of death or hospitalization in ALS patients over 18 months.
A retrospective study of 489,360 patients reveals that right-sided middle cerebral artery strokes are associated with significantly higher inpatient mortality and complications compared to left-sided strokes, likely due to inherent scoring
This review synthesizes findings on how periventricular white matter hyperintensities (PWMHs) drive cognitive impairment in Aβ-negative individuals through distinct metabolic mediation and direct structural pathways, highlighting the clinic
This randomized pilot study demonstrates that high-frequency TENS significantly improves specific neuropathic ocular pain symptoms over three months, offering a non-invasive, non-pharmacological alternative for patients with refractory ocul
A comprehensive review of a multicenter RCT (Morone et al., 2026) demonstrating that exoskeleton-based robot-assisted therapy significantly improves upper limb motor impairment and clinical outcomes in the early subacute phase of stroke rec
This study identifies somatic gene mutations in excitatory neurons of the motor cortex as a potential driver of sporadic ALS, challenging the traditional view of the disease’s genetic origins.
A large-scale analysis of the VA Million Veteran Program reveals that TBI, depression, and specific military environmental exposures significantly elevate the 10-year risk of Alzheimer’s and related dementias, highlighting critical targets
This review analyzes the ICSM Phase III study, highlighting how a structured empowerment program and standardized protocols in EMS significantly reduced prehospital delays and tripled alteplase administration rates for acute ischemic stroke
