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This study explores whether renal resistive index (RRI) changes during a transient elevation of mean arterial pressure (MAP) can guide individualized MAP targets to optimize renal function in early septic shock, finding that RRI decrease do
A nationwide cohort study reveals that two-thirds of patients with primary hyperparathyroidism exhibit end-organ damage at diagnosis or during follow-up, yet few receive parathyroidectomy, underscoring missed opportunities to reduce morbidi
Intensive blood pressure lowering post-thrombectomy increases acute kidney injury risk, which correlates with poorer neurological outcomes in stroke patients. Careful BP management is crucial to prevent renal complications and optimize reco
An expert consensus (STARDaki) extends STARD to improve reporting of diagnostic test accuracy studies for acute kidney injury (AKI), specifying patient selection, reference standards, timing, assay details and test-retest reliability.
A machine-learning model using perioperative hemodynamic indices accurately predicted stage 2-3 acute kidney injury after orthotopic heart transplantation in 114 patients, with light gradient boosting machine achieving AUC 0.898.
A predefined subanalysis of EAST-AFNET 4 shows early rhythm control safely reduces cardiovascular events in recently diagnosed AF patients with CKD, with a trend toward greater benefit in this high-risk group.
A historical analysis reveals that policy decisions, financial incentives, and for-profit dialysis centers have contributed to persistent underuse of home dialysis in the US, especially among marginalized populations.
A pooled analysis of four cohorts reveals that specific IgG N-glycosylation patterns are significantly associated with incident diabetic nephropathy, highlighting immune-related mechanisms in disease progression.
This nationwide US study analyzes 10,687 simultaneous liver-kidney transplants, highlighting increased use of DCD donors with machine perfusion and comparable outcomes to DBD transplants, supporting broader DCD adoption in selected patients
Acoramidis stabilizes transthyretin and shows kidney-protective effects in transthyretin amyloid cardiomyopathy by reducing eGFR decline and albuminuria, with an initial reversible dip in kidney function associated with improved clinical ou
Among U.S. veterans with diabetes on dialysis, continuous glucose monitoring (CGM) use was associated with significantly lower mortality risk compared to non-CGM use, highlighting CGM’s potential to improve survival in this high-risk
APOL1 high-risk genotypes significantly increase the risk of reduced kidney function after living kidney donation in Black donors, highlighting the need for genotype screening to improve donor risk stratification.
Thyroid hormone signaling may influence ADPKD progression, with preclinical cyst suppression and patient biomarker associations suggesting prognostic and therapeutic potential.
A prespecified pooled analysis of 18,991 participants found finerenone was associated with a significant reduction in sudden death across chronic kidney disease, type 2 diabetes, and heart failure populations.
In a large international prospective cohort of hospitalized patients with cirrhosis, chronic kidney disease was common, clustered with metabolic risk, and strongly associated with acute kidney injury, more decompensation, and higher in-hosp
A post hoc FIDELITY analysis suggests finerenone improves cardiovascular and kidney outcomes across CKM stages and may modestly shift patients toward CKM regression over time.
CRISPR-engineered GGTA1/B4GALNT2/SLA-DR knockout pigs remained healthy, screened negative for 55 zoonotic pathogens, and supported long-term renal xenograft function in rhesus monkeys when preformed anti-SLA antibodies were absent.
In a nationwide U.S. analysis of 21,010 adult DCD kidney transplants, normothermic regional perfusion lowered delayed graft function, shortened hospital stay, and improved graft and patient survival, with the greatest benefit in higher-risk
Higher proteinuria in preeclampsia was linked to greater long-term risk of maternal hypertension and chronic kidney disease, with overall increased risk of cardiovascular disease as well.
In a pre-specified exploratory analysis of SURPASS-CVOT, tirzepatide reduced major kidney events versus dulaglutide in people with type 2 diabetes and cardiovascular disease, mainly by lowering new macroalbuminuria and slowing eGFR decline.
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