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Mosaic loss of Y chromosome (mLOY) in men is strongly associated with diminished lung function, increased emphysema severity, and faster epigenetic aging, positioning mLOY as a novel biomarker for respiratory aging and COPD risk in males.
Emerging obesity pharmacotherapies targeting entero-pancreatic hormones deliver substantial weight loss and improve multiple obesity-related complications, heralding a treat-to-target paradigm in obesity management with personalized, compli
A genome-wide meta-analysis of 2.8 million individuals reveals genetic links between irritable bowel syndrome, brain-gut pathways, and cardiometabolic traits, highlighting novel therapeutic targets involving triglyceride metabolism.
A pragmatic RCT in an Australian ICU found the ABCDEF bundle did not reduce delirium incidence or duration but improved patients’ ability to perform usual activities at 90 days post-discharge, suggesting possible long-term quality of
A VA pilot study shows that pharmacist-led provision and 12-month dispensing of hormonal contraception is feasible, improves access, and enhances satisfaction among women Veterans and pharmacists.
This study examines how temporal cortisol secretion changes in benign adrenal incidentalomas relate to long-term cardiometabolic outcomes and mortality, highlighting the significance of persistent mild autonomous cortisol secretion for hype
Prolonged mild sleep restriction of 1.5 hours per night over six weeks leads to modest weight gain, increased adiposity, and elevated leptin levels, highlighting the importance of adequate sleep in weight management and cardiometabolic risk
This study highlights how enhanced social support within primary care teams correlates with lower turnover intentions, emphasizing the potential of network-based interventions to improve workforce stability and well-being in healthcare sett
A NIDDK workshop highlighted the crucial role of real-world evidence in addressing gaps about GLP-1 receptor agonists’ safety, effectiveness, adherence, and economic impact to improve clinical and regulatory decision-making.
This article reviews the incidence and predictors of recurrent VTE following anticoagulation for isolated distal deep vein thrombosis, highlighting key risk factors and implications for treatment duration and patient management.
A randomized trial showed no significant differences in 6- and 12-month cognitive, physical, and quality of life outcomes between early restrictive and liberal fluid resuscitation in sepsis-induced hypotension.
The Predictive Aplastic Score System (PASS) accurately distinguishes acquired aplastic anemia from inherited bone marrow failure syndromes using seven clinical variables, enabling rapid diagnosis and improved treatment decisions in adults.
A 12-week randomized trial explored sleep optimization in adults with type 1 diabetes, revealing improved sleep quality and reduced diabetes distress but limited glycemic benefits except in patients with baseline A1C ≥7%.
In frail elderly Asian AF patients stable on warfarin, transitioning to DOACs increased risks of bleeding, thromboembolic events, and mortality, emphasizing cautious individualized management.
Iterative redesign of electronic health record (EHR) portal reminders significantly improved mammography screening adherence in an outpatient setting, demonstrating the value of concise messages with scheduling links, while retinal and HbA1
From 2017 to 2022, general internal medicine inpatient volume increased notably, yet patient complexity remained stable; however, imaging utilization surged, highlighting evolving resource demands in hospital care.
APOL1 high-risk genotypes significantly increase the risk of reduced kidney function after living kidney donation in Black donors, highlighting the need for genotype screening to improve donor risk stratification.
Machine learning analysis of brief patient-physician conversations using acoustic speech features can effectively screen for cognitive impairment in primary care settings, enabling scalable early detection.
A 2026 RCT assessed telehealth stepped alcohol treatment in chronic liver disease patients, finding significant reductions in weekly alcohol consumption but no difference in achieving moderate drinking levels compared to usual care.
Analyzing 54 million adults in England reveals rising obesity rates from 2019-2025, disproportionately affecting socioeconomically deprived, ethnic minority, and younger adult groups, with widening inequalities intensified during the COVID-
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