Augmented mean arterial pressure (>85-90 mm Hg) did not improve 6-month motor or sensory neurologic recovery after acute spinal cord injury compared to conventional targets (>65-70 mm Hg).
Higher blood pressure targets were associated with increased organ dysfunction, prolonged mechanical ventilation, and more respiratory complications.
The study raises critical questions about the routine practice of aggressive blood pressure augmentation in spinal cord injury care.
Further research is needed to identify subpopulations who might benefit and to elucidate mechanisms behind adverse effects.
Study Background and Disease Burden
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