Section
Serum GFAP elevation predicts progression independent of relapse in MS; therapy-induced GFAP reduction associates with decreased progression risk, supporting GFAP as a biomarker for progression risk stratification and treatment monitoring.
This review synthesizes evidence from a large-scale multi-ancestry study revealing ancestry-specific distributions of Parkinson’s disease genetic variants, emphasizing the need for diverse population inclusion to optimize diagnosis an
A single moderate COPD exacerbation markedly increases future exacerbation risk and long-term mortality, justifying its reclassification as high risk per GOLD 2026 guidelines and supporting refined risk stratification for better clinical ma
This review synthesizes evidence on patients’ perceptions of telehealth for head and neck cancer surveillance, highlighting barriers, benefits, and the potential of hybrid models to improve acceptability post-treatment.
Postoperative colonic ischemia is a rare but severe complication after colectomy for colorectal cancer, primarily linked to specific resection types and vascular comorbidities, significantly impacting patient morbidity and mortality.
Oral nicotinamide reduces keratinocyte carcinoma incidence in high-risk individuals, providing significant cost savings and quality-adjusted life-year gains, supporting its role as a cost-effective preventive strategy.
This review synthesizes evidence on how the timing of hard palate closure affects maxillary growth in patients with cleft lip, alveolus, and palate, highlighting comparable outcomes after early and delayed closure and evaluating the influen
Peer networks in adolescence, especially in upper secondary school, significantly influence the risk trajectory for mental disorders through peers’ diagnosed conditions and genetic predispositions, with subtype-specific and cross-diso
This review synthesizes contemporary evidence on initiation, adherence, and persistence of guideline-directed medical therapy after heart failure hospitalization, highlighting critical gaps and strategies to improve long-term patient outcom
This review synthesizes key findings evaluating olorofim’s clinical effectiveness and safety in patients with refractory disseminated coccidioidomycosis, emphasizing its potential role amid limited treatment options.
This review synthesizes evidence linking periodontitis-induced inflammation with clonal hematopoiesis, exploring implications for tumor metastasis, trial methodology, and microbiome-host crosstalk.
This review synthesizes evidence on the role of RNA-binding protein G3BP2 in conferring venetoclax resistance in AML through stabilizing ELF1 mRNA and upregulating MCL1 transcription, highlighting novel therapeutic avenues combining G3BP2 i
This review synthesizes current evidence on the impact of hypoglossal nerve stimulation (HGNS) on cardiovascular disease incidence in obstructive sleep apnea patients, highlighting potential long-term cardiovascular benefits and mechanistic
This review synthesizes evidence linking long-term exposure to PM2.5 constituents—particularly elemental carbon, organic carbon, and nitrate—with increased coronary heart disease and acute myocardial infarction risks in China, emphasizing t
Medically tailored groceries modestly improve HbA1c and significantly enhance food and nutrition security among Medicaid-insured adults with type 2 diabetes, supporting ‘Food Is Medicine’ strategies in chronic disease management
This review synthesizes evidence on 2-year psychiatric and neurologic risks post infections across body systems and age groups, highlighting infection-specific risk profiles, age-dependent vulnerability, and mechanistic insights from recent
This review synthesizes current evidence on the effectiveness of adjuvanted RSVPreF3 vaccination in reducing RSV-related hospitalizations among older US adults, highlighting substantial protection across high-risk subgroups.
Emergency departments serve as vital venues for hepatitis C virus screening, particularly for persons experiencing homelessness who exhibit higher HCV prevalence and face healthcare access barriers. Evidence supports nontargeted screening i
Medicare Advantage beneficiaries with cancer receive guideline-concordant treatment similarly to Traditional Medicare enrollees but at lower costs and comparable timeliness, highlighting implications for healthcare policy and cost-effective
Recent decades saw increased anticoagulant use and reduced stroke risk in elderly AF patients, especially with DOACs, but bleeding risks rise notably in very elderly patients, highlighting tailored management needs.
