Section
Mosaic loss of Y chromosome (mLOY) in men is strongly associated with diminished lung function, increased emphysema severity, and faster epigenetic aging, positioning mLOY as a novel biomarker for respiratory aging and COPD risk in males.
RCT evidence shows that restrictive low-use versus liberal high-use physical restraint strategies in mechanically ventilated ICU patients do not differ in days alive without delirium or coma at 14 days.
This review synthesizes recent phase I trial data on CD7 CAR-T therapies in relapsed/refractory AML, highlighting promising safety, high response rates, challenges with antigen loss relapse, and avenues for future research.
Distinct baseline foveal tomographic lesions predict foveal-first versus extrafoveal-first cRORA onset in iAMD. Hyperreflective foci and lesion type inform risk stratification and timing of atrophic progression relevant for emerging dry AMD
This review synthesizes evidence linking ischemic placental disease—comprising preeclampsia, placental abruption, and fetal growth restriction—with increased postpartum maternal risk of neurological and psychiatric hospitalizations within o
This review synthesizes evidence from the WAFER trial and related studies comparing WALANT to GA/RA in flexor tendon repair, highlighting functional outcomes, safety, cost-effectiveness, and patient-centered benefits including earlier retur
The STAR trial demonstrates that trauma-focused CBTp is a safe, effective intervention for adults with co-occurring PTSD and psychosis, improving PTSD and psychosis symptoms, with high acceptability and minimal adverse events.
This review synthesizes evidence from the ARTEMIS trial and related studies on community-based adolescent mental health care and stigma reduction, highlighting intervention efficacy, implementation challenges, and translational potentials i
A large RCT found that adding behavioral therapies to patient-centered opioid tapering did not improve taper success at 12 months, though CBT may reduce adverse effects; complementary digital support programs show feasibility but require fu
Systemic nicotinamide supplementation is associated with reduced risk of POAG development in ocular hypertension, improved retinal function, and better quality of life, suggesting its neuroprotective potential as an adjunctive therapy in gl
This review synthesizes evidence on AR-guided single-encounter localization for early-stage lung cancer, highlighting its noninferiority to CT-guided methods with benefits in patient comfort, radiation reduction, and procedural efficiency.
Oral decitabine/cedazuridine plus venetoclax provides an effective, fully oral frontline therapy for older or unfit patients with AML, showing encouraging response rates and manageable safety with long-term follow-up, highlighting particula
Reviewing ADA 2022 vs ACOG criteria and timing effects on postpartum OGTT in GDM women reveals inpatient testing increases screening uptake but varies in diabetes classification; highlights the need for consensus on test timing and interpre
The HumAn-1 trial found no significant differences between insulin glargine and human isophane insulin in hypoglycemia risk or glucose control in young T1D patients in low-resource settings, underscoring accessibility over insulin type in t
This review synthesizes evidence that high adolescent cardiorespiratory fitness slightly elevates early adult atrial fibrillation risk but substantially reduces cardiovascular disease incidence later in life, with familial confounders accou
Combining circulating methylated SEPT9 with alpha-fetoprotein significantly enhances early hepatocellular carcinoma detection in cirrhotic patients, outperforming AFP alone and allowing improved surveillance sensitivity and specificity.
This review synthesizes randomized trial evidence demonstrating that intermittent theta burst stimulation (iTBS) targeting the dorsomedial PFC modulates default mode network activity, enhancing expectancy-driven placebo mood responses in de
Postoperative GLP-1RA initiation after liver resection for hepatocellular carcinoma in type 2 diabetes patients is associated with improved recurrence-free and overall survival compared to DPP-4 inhibitors, indicating potential incremental
Hypothyroidism increases the incidence of CABG and is linked to higher risks of postoperative complications, heart failure, stroke, and major adverse cardiovascular events, highlighting the importance of preoperative thyroid function optimi
Menaquinone-7 (MK-7) supplementation over two years significantly slows progression of coronary artery calcification (CAC) in symptomatic coronary artery disease patients, with favorable safety and potential implications for plaque stabiliz
