Section
This review synthesizes evidence on the cost-effectiveness of the FMF first-trimester screening strategy for preterm preeclampsia in the UK compared to NICE recommendations, highlighting clinical efficacy, economic benefits, and implication
Cerebral small vessel disease (SVD) significantly contributes to functional decline independently of bleeding or ischemic events during antithrombotic therapy, underscoring the need for targeted management strategies to address SVD burden i
This review synthesizes evidence on staged, bilateral MRgFUS pallidothalamic tractotomy for Parkinson’s motor complications, highlighting demonstrated unilateral safety and modest bilateral efficacy with increased adverse events, unde
This review synthesizes evidence linking the 2025 Primary Aldosteronism Severity Classification (PASC) with adrenal venous sampling (AVS) lateralization and treatment outcomes, highlighting its potential to enhance precision in PA managemen
This review synthesizes evidence demonstrating that implementing full quadruple GDMT (ARNI, β-blockers, MRAs, SGLT2i) in HFrEF reduces hospitalization risks and healthcare costs, often yielding net savings despite medication expenses.
In frail elderly Asian AF patients stable on warfarin, transitioning to DOACs increased risks of bleeding, thromboembolic events, and mortality, emphasizing cautious individualized management.
Emerging evidence indicates that radiation dose to the left anterior descending coronary artery better predicts cardiac events than whole-heart dose in breast radiotherapy, emphasizing the importance of LAD-based planning to reduce long-ter
This review synthesizes evidence linking neuroretinal layer thinning observed by OCT with glycemic control and diabetic retinal disease in youth with type 1 diabetes, emphasizing early neurodegeneration preceding vascular changes and its po
This review synthesizes evidence on factors influencing delays in postoperative radiotherapy for head and neck cancer in rural settings, emphasizing communication, coordination, and community resources to inform strategies that improve care
This review synthesizes current evidence on the modified sleep apnea severity index (mSASI) as a composite metric integrating clinical and sleep study factors to predict cardiovascular risk in CPAP-intolerant OSA patients undergoing surgery
This review synthesizes current evidence linking adverse childhood experiences with increased risk and features of PCOS, highlighting possible neuroendocrine mechanisms and clinical implications for reproductive health management.
This review synthesizes evidence on the lower prevalence and fulfillment rates of postpartum permanent contraception requests among incarcerated individuals compared to community counterparts, underscoring reproductive justice and health eq
This review examines the impact of traumatic brain injury on the accuracy of Alzheimer disease blood biomarkers, highlighting reduced diagnostic performance in TBI-affected populations and the implications for clinical interpretation.
This review synthesizes evidence on neurofilament light chain (NFL) as a minimally invasive plasma biomarker predictive of diabetic retinopathy progression and vascular complications, based on integrated intraocular-plasma proteomics and mu
This review synthesizes evidence from a pioneering nonrandomized trial demonstrating that intravenous AAVrh.10hFXN gene therapy is safe and may improve cardiac outcomes in Friedreich ataxia cardiomyopathy, highlighting translational advance
This review synthesizes evidence on swallowing function and perioperative complications following transoral robotic surgery (TORS) for oropharyngeal squamous cell carcinoma (OPSCC), highlighting excellent short-term swallowing outcomes and
Pregabalin, a neuromodulator, significantly improves symptoms in the majority of patients with chronic neurogenic cough, offering a well-tolerated treatment option irrespective of gender or gastrointestinal comorbidities.
This review synthesizes evidence on preS1 antigen and anti-preS1 IgG dynamics in chronic hepatitis B, highlighting their correlations with viral replication, liver inflammation, and functional cure, and elucidates the neutralising potential
The MAPLE-HCM trial demonstrates aficamten monotherapy significantly outperforms metoprolol in improving exercise capacity, hemodynamics, and patient-reported outcomes in obstructive hypertrophic cardiomyopathy (oHCM), supporting aficamten
This review synthesizes current evidence on CSF TMEM106B levels in FTLD, highlighting their associations with disease severity, genetic variants, brain atrophy, and clinical progression, emphasizing TMEM106B’s potential as a biomarker
