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The OCEANIC-STROKE randomized trial demonstrates that adding asundexian to antiplatelet therapy reduces ischemic stroke without a significant rise in major bleeding, though it increases lower gastrointestinal bleeding in patients with nonca
Higher cumulative inotropic exposure during VA ECMO support in cardiogenic shock is associated with increased risk of ECMO weaning failure, mortality, arrhythmias, and delayed lactate clearance, highlighting the need for prospective trials
Prominent left atrial V waves in heart failure with preserved ejection fraction significantly increase right ventricular afterload independent of pulmonary vascular disease, challenging current hemodynamic assessments and impacting patient
This study reveals that various combinations of daily step counts and stepping intensity independently reduce all-cause and cardiovascular mortality, highlighting the importance of personalized physical activity strategies.
Rare coding variants in the FOXF1 gene are linked to pulmonary arterial hypertension (PAH), implicating impaired endothelial FOXF1 expression and disrupted BMPR2 regulation in disease development.
This article explores how palmitic acid induces a pro-hypertrophic memory in cardiomyocytes through epigenetic regulation involving KDM5A and H3K4me3 modifications, driving cardiac hypertrophy and heart failure, and highlights potential the
Transcatheter tricuspid-valve repair plus medical therapy significantly improves survival, reduces heart failure hospitalizations, and enhances quality of life in patients with severe tricuspid regurgitation compared to medical therapy alon
This article explores recent meta-analytic evidence on how device-measured physical activity and sedentary behavior relate to cardiometabolic risk markers in children and adolescents, revealing nuanced benefits of moderate-to-vigorous exerc
This review synthesizes evidence on the derivation and validation of a claims-based algorithm for identifying cardiogenic shock (CS), demonstrating its high diagnostic performance and enabling robust large-scale epidemiologic and long-term
Paramedic-suspected STEMI identified a heterogeneous, high-acuity population where 60% had confirmed STEMI; outcomes vary by final diagnosis, underscoring the need for rapid reperfusion with early diagnostic refinement.
An expert consensus provides practical, evidence-informed guidance for clinicians to protect people with cardiovascular disease from rising heat extremes, focusing on prevention, medication review, cooling strategies, and health-system prep
Retrospective multi-center data demonstrate that sotatercept improves functional status, exercise capacity, and hemodynamics in children with pulmonary hypertension, with a manageable safety profile.
PCSK9 inhibitors significantly reduce the risk of retinal vascular occlusions compared to other lipid-lowering therapies in patients with hyperlipidemia, highlighting their potential as a neuroprotective cardiovascular intervention.
TBX2 is identified as a key transcription factor repressing vascular calcification by controlling RUNX2 and the inflammatory NLRP3 pathway, highlighting new therapeutic targets to reduce cardiovascular risk in CKD.
This review synthesizes evidence on dual antiglutamate therapy combining AMPA and NMDA receptor blockade in postanoxic super-refractory status epilepticus, highlighting the SUPER-CAT study’s demonstration of improved seizure resolutio
Recent guideline updates elevate intravascular ultrasound (IVUS) and optical coherence tomography (OCT) from optional tools to Class I, Level A strategies for many complex percutaneous coronary interventions, driven by randomized trials and
The CONDUCT-AF trial demonstrated that conduction system pacing is non-inferior to biventricular pacing for improving LVEF at 6 months in patients with refractory AF and HF undergoing AV node ablation, with procedural advantages favoring CS
A large cohort study highlights how acquired cardiovascular risk factors significantly influence late mortality in adults with congenital heart disease, underscoring the need for integrated care strategies.
This multicenter Chinese registry study reveals a high incidence of in-hospital cardiac arrest with low survival rates and highlights critical gaps in postresuscitation care and systemic factors limiting outcomes.
The oxidized phospholipid PGPC inhibits angiogenesis in ischemic heart disease by impairing endothelial autophagic flux through NPC1-induced acetylation and ubiquitination of syntaxin 17, unveiling new potential therapeutic targets for coro
