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The IPAD randomized trial shows no significant difference in delayed gastric emptying rates between side-to-side and end-to-side gastrojejunostomy after pancreatoduodenectomy, with comparable postoperative outcomes and quality of life.
A prospective cohort study reveals a lower-than-expected prevalence of uterine fibroids among reproductive-aged Latina women in the US, highlighting age-related risk and associations with reproductive factors.
This study clarifies that cervical cord atrophy in MS is partly disease-specific beyond aging effects, with distinct patterns linked to age and disease onset, correlating with disability and neurodegeneration markers.
Rapid whole-genome sequencing (WGS) in pediatric neurology inpatients yields nearly 50% diagnostic confirmation, significantly influencing patient management and supporting early genomic testing beyond neonatal intensive care units.
Early disclosure of plasma p-tau217 and NfL biomarkers significantly improves diagnostic confidence and clinical decisions in cognitive decline without increasing emotional distress, supporting their integration into routine memory clinic c
A national cohort study reveals significant gaps in the diagnosis and pharmacologic treatment of adults with laboratory-confirmed diabetes, highlighting the impact of glycemic severity and comorbidities on care delivery.
Ocular proton therapy in uveal melanoma induces significant reductions in corneal nerve parameters with partial recovery by 12 months, while corneal sensitivity remains stable and patient-reported symptoms show limited correlation with stru
This study evaluates how clonal hematopoiesis of indeterminate potential (CHIP) and pre-treatment neutropenia affect clinical outcomes and toxicities in patients undergoing CAR-T therapy for hematologic cancers, revealing nuanced risks for
Emerging therapies have revolutionized first-line treatment in large B-cell lymphoma, but inconsistent trial designs and biomarker use create complexity. Harmonized strategies integrating biomarkers, pooled data, AI, and regulatory collabor
This study examines workplace stressors, burnout, and support needs of home health aides caring for older adults, highlighting significant challenges including racism, violence, and care complexities, and proposes targeted interventions to
This article explores leadership perspectives on equity in Hospital at Home (HaH) programs, highlighting strategies to broaden access, eliminate enrollment barriers, and address health disparities for more equitable acute care delivery.
This study compares PSA screening and biopsy rates between Veterans Affairs and Fee-for-Service Medicare, revealing that VA care is more closely aligned with patients’ likelihood of benefit, particularly in older men and those with li
The PACER trial demonstrates that peer-supported internet-based CBT significantly reduces anxiety in ED patients with low-risk chest pain, with pronounced benefits in severe anxiety cases, supporting telehealth CBT as an effective anxiety t
Physiotherapist-supervised exercise therapy combined with education significantly enhances knee function and muscle strength in young adults with persistent knee issues post-ACL reconstruction, with benefits lasting up to 12 months.
This retrospective study evaluates survival outcomes and risk factors associated with allogeneic hematopoietic cell transplantation in young adults (18-40 years) with myelodysplastic syndrome, revealing encouraging survival rates and highli
This analysis of BMT CTN 1202 reveals that rabbit ATG exposure influences survival, relapse, and immune recovery after T-replete hematopoietic cell transplantation, advocating for model-based dosing to optimize outcomes.
This review synthesizes evidence from the ELEVATE trial on adding cusatuzumab, a CD70-targeting antibody, to venetoclax with or without azacitidine in unfit AML patients, highlighting therapeutic potential, safety concerns, and translationa
This review synthesizes emerging evidence comparing high-dose anti-CD25 (without methotrexate) versus low-dose anti-CD25 (with methotrexate) strategies for GVHD prophylaxis in haplo-HSCT, highlighting improved acute GVHD control and GRFS wi
CHIP and pre-treatment neutropenia do not significantly affect survival or main toxicities in CAR-T therapy for hematologic cancers but may predict specific inflammatory toxicities, indicating distinct risk profiles for patient management.
This article explores novel therapeutic strategies in acute myeloid leukemia by combining PI3K inhibitors with EZH1/2 dual inhibitors to overcome epigenetic resistance mechanisms in leukemic stem cells, offering promising pathways to preven
