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Recent guideline updates elevate intravascular ultrasound (IVUS) and optical coherence tomography (OCT) from optional tools to Class I, Level A strategies for many complex percutaneous coronary interventions, driven by randomized trials and
The CONDUCT-AF trial demonstrated that conduction system pacing is non-inferior to biventricular pacing for improving LVEF at 6 months in patients with refractory AF and HF undergoing AV node ablation, with procedural advantages favoring CS
A large cohort study highlights how acquired cardiovascular risk factors significantly influence late mortality in adults with congenital heart disease, underscoring the need for integrated care strategies.
This multicenter Chinese registry study reveals a high incidence of in-hospital cardiac arrest with low survival rates and highlights critical gaps in postresuscitation care and systemic factors limiting outcomes.
The oxidized phospholipid PGPC inhibits angiogenesis in ischemic heart disease by impairing endothelial autophagic flux through NPC1-induced acetylation and ubiquitination of syntaxin 17, unveiling new potential therapeutic targets for coro
This post hoc analysis of the PREVENT trial highlights that preventive PCI significantly reduces adverse cardiac events in patients with vulnerable lipid-rich plaques, identified by near-infrared spectroscopy, underscoring the importance of
A randomized trial found no significant difference in delayed gastric emptying rates between side-to-side and end-to-side gastrojejunostomy after pancreatoduodenectomy, with comparable postoperative outcomes and quality of life.
FGF18 produced by stromal fibroblasts promotes AML progression via FGFR3-mediated AKT-mTOR signaling, forming a feed-forward loop that impairs CD8+ T-cell immunity. Neutralizing FGF18 synergizes with PD-1 blockade, suggesting a novel therap
This study demonstrates that one-stage assay (OSA) factor VIII activity better reflects the functional enhancement of AAV-derived FVIII in hemophilia A gene therapy, offering superior prediction of bleeding phenotype compared to chromogenic
This study investigates how dose reductions and discontinuations of antifibrotic therapies influence disease progression in idiopathic pulmonary fibrosis (IPF), revealing significant challenges in drug tolerability and the need for improved
A large retrospective study found that oral corticosteroids for ABPA in cystic fibrosis improve lung function, while adding antifungals offers no significant additional benefit in clinical outcomes.
White blood cell count modifies mortality outcomes in sepsis patients treated with cefepime versus piperacillin-tazobactam, suggesting its potential role in guiding antibiotic selection.
Occupational exposure to both dust and fumes significantly increases the risk of future respiratory exacerbations, atherosclerotic cardiovascular disease, and pneumonia in smokers and former smokers, underscoring the need for targeted preve
This randomized trial compares aflibercept monotherapy versus combined with reduced-fluence photodynamic therapy for PCV, highlighting OCTA metrics that predict polypoidal lesion closure and treatment response over 52 weeks.
Ultra-widefield swept-source OCT excels in assessing small-to-medium choroidal tumors, outperforming SD-OCT and providing detailed structural insights with noninvasive precision, though larger or complex tumors benefit from multimodal imagi
Functional rhinoplasty improves nasal obstruction symptoms and these disease-specific improvements correlate with reductions in anxiety, depression, and pain/discomfort, influencing long-term global quality of life.
This study compares the mechanical properties of slide tracheoplasty and end-to-end anastomosis in porcine tracheas, revealing lower tensile strength but greater force dispersion in slide tracheoplasty, with implications for airway reconstr
This two-center randomized trial assessed near-infrared autofluorescence imaging to identify parathyroid glands during total thyroidectomy. Despite higher gland identification rates, the technology did not reduce hypoparathyroidism incidenc
This nationwide Danish study reveals that younger patients exhibit significantly higher recurrence rates after primary ventral hernia repair than older patients, highlighting the need for age-specific preoperative counseling.
This pooled analysis from COG studies reveals that after accounting for tumor biology, age, tumor nephrectomy weight, and diameter are not independently predictive of outcomes in stage I/II favorable histology Wilms tumor, refining risk str
