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The STOPS trial demonstrates noninferiority of subtotal colectomy with cecorectal anastomosis compared to total colectomy with ileorectal anastomosis for refractory slow-transit constipation at 1 year, balancing symptom relief with postoper
A randomized clinical trial demonstrates that a self-guided internet intervention significantly reduces seizure frequency and improves anxiety in adults with functional seizures, offering a scalable treatment alternative to standard care.
A virtual aerobic exercise program significantly improves recovery speed and quality of life in youth with prolonged concussion, especially when initiated within three months of injury, outperforming stretching interventions.
This two-center randomized trial assessed near-infrared autofluorescence imaging to identify parathyroid glands during total thyroidectomy. Despite higher gland identification rates, the technology did not reduce hypoparathyroidism incidenc
Physiotherapist-supervised exercise therapy combined with education significantly enhances knee function and muscle strength in young adults with persistent knee issues post-ACL reconstruction, with benefits lasting up to 12 months.
The CHOICE trial investigated whether hearing aid intervention reduces dementia progression in older adults with mild cognitive impairment and hearing loss, finding no significant reduction in dementia incidence but increased cognitive impr
A large-scale randomized trial demonstrates that 38% silver diamine fluoride effectively arrests dentin caries lesions in young children with severe early childhood caries, offering a safe, noninvasive treatment option and supporting FDA ap
This review synthesizes current evidence on ruxolitinib 1.5% cream efficacy and safety in cutaneous lichen planus, highlighting significant lesion and pruritus reduction in a pivotal phase 2 RCT, supporting its potential as a novel topical
This clinical trial compares ultrasound-guided transvaginal drainage to laparoscopy for tubo-ovarian abscess evacuation, highlighting differences in cure rates, reintervention frequency, and recovery outcomes.
A randomized clinical trial demonstrated that the 5x-multiplier algorithm significantly reduces opioid prescriptions at discharge without increasing consumption, refill rates, or patient dissatisfaction after major abdominal cancer surgery
A recent randomized trial shows that adding intravenous immunoglobulin (IVIG) to high-dose prednisone significantly improves muscle strength and disease activity in newly diagnosed idiopathic inflammatory myopathies with rapid and clinicall
This review synthesizes evidence from the TEASE-1 trial and related studies on gildeuretinol acetate, highlighting its safety profile and modest efficacy in slowing retinal atrophic lesion growth in Stargardt disease over 24 months.
The DASH4D diet, a tailored DASH-style intervention for diabetes, significantly improved key glycemic biomarkers including fructosamine, fasting glucose, and HbA1c compared to a typical American diet in adults with type 2 diabetes.
A randomized clinical trial shows online team-based care is as effective as conventional in-person treatment for atopic dermatitis, offering an accessible alternative for chronic disease management.
A large randomized clinical trial demonstrated that preoperative high-dose corticosteroids do not reduce major postoperative complications in elective digestive cancer surgery, challenging their routine use for perioperative inflammation co
Endoscopic sinus surgery significantly improves quality of life in adults with recurrent acute rhinosinusitis compared to medical treatment alone, demonstrating its safety and efficacy in managing this burdensome condition.
A landmark randomized trial demonstrates that multilevel stepped reminders targeting both primary care physicians and patients markedly improve adherence to annual lung cancer screening, while health communication alone may be insufficient
This randomized trial compared connectivity-based versus scalp-based targeting of accelerated TMS in treatment-resistant depression, showing greater antidepressant effects with individualized connectivity-guided targeting.
This pilot randomized trial demonstrates the feasibility of using low-dose colchicine after acute intracerebral hemorrhage to prevent vascular events, highlighting considerations for future larger studies regarding recruitment, adherence, a
The phase 3 TORCH trial demonstrates that adding selective radiofrequency ablation after transarterial chemoembolization significantly improves progression-free and overall survival in patients with unresectable liver-confined hepatocellula
