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This review synthesizes evidence from a 2025 randomized clinical trial evaluating a tailored weight loss program, CoachToFit, for veterans with serious mental illness, highlighting its potential to improve weight outcomes via remote support
A randomized clinical trial demonstrates that combining gastric electrical stimulation with pyloroplasty significantly outperforms pyloroplasty alone, providing superior symptom relief and reducing hospitalizations for patients with medicat
Recent robust randomized trials demonstrate that smartphone-delivered digital cognitive behavioral therapy provides significant, sustained improvements in generalized anxiety disorder, overcoming key access barriers and highlighting its pot
The KARMA-Dep 2 trial reveals that serial ketamine infusions do not significantly outperform midazolam in reducing depressive symptoms among inpatients receiving usual psychiatric care, challenging assumptions about ketamine’s long-term ant
The EMAGINE randomized clinical trial assessed low-intensity electromagnetic stimulation combined with rehabilitation in moderate to severe ischemic stroke patients. While safe, it did not yield statistically significant functional improvem
A factorial RCT in food-insecure adults with hypertension found that healthy food subsidies modestly reduced blood pressure compared with delivered food boxes, while lifestyle counseling and longer duration showed no added benefit.
AI-driven transcutaneous peripheral nerve stimulation (TPNS) shows significant improvements in upper limb function for essential tremor (ET), supporting a promising noninvasive treatment approach with manageable safety profile over 90 days.
A digital health program significantly increased lung cancer screening rates among high-risk individuals, underscoring digital tools’ potential to improve preventive care.
A phase 2b trial reveals that single doses of MM120 produce dose-dependent reductions in anxiety symptoms in adults with moderate to severe generalized anxiety disorder, paving the way for phase 3 studies.
Second-generation heart rate variability biofeedback (HRVB) shows promise in reducing craving, negative affect, and substance use in adults with substance use disorder (SUD), supporting its potential as an adjunctive treatment in early reco
A 16-week Mediterranean diet intervention significantly reduced psoriasis severity and improved metabolic markers in patients with mild to moderate disease, suggesting diet’s role as adjunctive therapy in psoriasis management.
This review synthesizes evidence on high-dose versus standard-dose influenza vaccines for cardiovascular outcomes in older adults, focusing on the large DANFLU-2 trial and complementary studies, highlighting modest cardiovascular benefits a
A large randomized clinical trial demonstrated that the 23-valent pneumococcal polysaccharide vaccine (PPV23) did not significantly reduce fatal or nonfatal acute coronary syndrome and ischemic stroke among middle-aged adults at increased c
The FiiRST-2 trial found no superiority of clotting factor concentrates over frozen plasma for initial resuscitation in severely bleeding trauma patients, with similar transfusion needs and safety outcomes.
A phase 2 trial in adults with major depressive disorder demonstrated that ammoxetine at 40 mg/d and 60 mg/d significantly improved depressive symptoms compared to placebo and was generally well tolerated, offering a novel treatment option
Perispinal etanercept is safe but does not improve quality of life in chronic stroke patients, as demonstrated by a Class I randomized trial; translational implications and future research directions are discussed.
A multisite randomized trial demonstrates that acupuncture, both standard and enhanced, significantly improves chronic low back pain-related disability in older adults compared to usual medical care, with sustained benefits and a favorable
This review discusses the randomized clinical trial evaluating germicidal UV light in long-term care facilities, highlighting its modest efficacy in reducing acute respiratory infections and its potential role in infection control for older
The large-scale COSMOS trial reveals that while long-term cocoa extract supplementation does not reduce overall incident hypertension in older adults, it significantly lowers risk among individuals with normal baseline systolic blood pressu
A large UCLA Health randomized clinical trial found that usual care via mailed FIT outreach outperformed active choice strategies in colorectal cancer screening uptake among adults aged 45 to 49 years, highlighting the challenges in engagin
