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A 16-week Mediterranean diet intervention significantly reduced psoriasis severity and improved metabolic markers in patients with mild to moderate disease, suggesting diet’s role as adjunctive therapy in psoriasis management.
This review synthesizes evidence on high-dose versus standard-dose influenza vaccines for cardiovascular outcomes in older adults, focusing on the large DANFLU-2 trial and complementary studies, highlighting modest cardiovascular benefits a
A large randomized clinical trial demonstrated that the 23-valent pneumococcal polysaccharide vaccine (PPV23) did not significantly reduce fatal or nonfatal acute coronary syndrome and ischemic stroke among middle-aged adults at increased c
The FiiRST-2 trial found no superiority of clotting factor concentrates over frozen plasma for initial resuscitation in severely bleeding trauma patients, with similar transfusion needs and safety outcomes.
A phase 2 trial in adults with major depressive disorder demonstrated that ammoxetine at 40 mg/d and 60 mg/d significantly improved depressive symptoms compared to placebo and was generally well tolerated, offering a novel treatment option
Perispinal etanercept is safe but does not improve quality of life in chronic stroke patients, as demonstrated by a Class I randomized trial; translational implications and future research directions are discussed.
A multisite randomized trial demonstrates that acupuncture, both standard and enhanced, significantly improves chronic low back pain-related disability in older adults compared to usual medical care, with sustained benefits and a favorable
This review discusses the randomized clinical trial evaluating germicidal UV light in long-term care facilities, highlighting its modest efficacy in reducing acute respiratory infections and its potential role in infection control for older
The large-scale COSMOS trial reveals that while long-term cocoa extract supplementation does not reduce overall incident hypertension in older adults, it significantly lowers risk among individuals with normal baseline systolic blood pressu
A large UCLA Health randomized clinical trial found that usual care via mailed FIT outreach outperformed active choice strategies in colorectal cancer screening uptake among adults aged 45 to 49 years, highlighting the challenges in engagin
A cluster randomized trial in veterans assessed peer coaching for weight management, showing improved program attendance but no significant 12-month weight loss difference versus enhanced usual care.
A randomized clinical trial demonstrates that personalized high-definition transcranial direct current stimulation (HD-tDCS) significantly improves mood in patients with moderate to severe depression, showing faster and comparable effect si
This trial assessed if videos and infographics from primary care physicians improve flu vaccination rates; overall effects were minimal, but notable improvements occurred in children.
The Smart-T smartphone intervention significantly improves 7-day smoking abstinence at 26 weeks in low-income adults, outperforming the standard QuitGuide app when combined with nicotine replacement therapy.
A 4-week randomized trial shows that low-dose cannabidiol (CBD) may cause transient liver enzyme elevations in healthy adults, emphasizing the need for vigilance and further safety assessment of consumer CBD products.
This review synthesizes recent evidence from the ACTIV-6 trial showing metformin does not significantly reduce symptom duration in low-risk adults with COVID-19, addressing safety, clinical outcomes, and translational insights.
A randomized clinical trial in Uganda compared standard open anterior mesh repair with a modified technique addressing femoral hernias, demonstrating both methods as safe and effective options for women’s groin hernia repair in low-re
A randomized clinical trial in South Australian long-term care facilities found germicidal UV light appliances did not significantly reduce acute respiratory infection rates per cycle but modestly lowered total infections over time, suggest
A large pragmatic trial demonstrates that daily emollient application starting before 9 weeks of age significantly reduces the risk of atopic dermatitis by 24 months in infants not selected for high risk, offering a feasible preventive appr
A randomized trial demonstrates that iodine-impregnated drapes significantly reduce pocket contamination and cardiac implantable electronic device infections in repeat surgeries, offering a simple, cost-effective prophylactic intervention.