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The phase 3 TORCH trial demonstrates that adding selective radiofrequency ablation after transarterial chemoembolization significantly improves progression-free and overall survival in patients with unresectable liver-confined hepatocellula
The BOOTS multicenter RCT found no significant difference in long-term effectiveness between dialectical behavior therapy (DBT) and schema therapy (ST) for borderline personality disorder (BPD), with both treatments yielding substantial cli
This review synthesizes evidence from the ARTEMIS trial and related studies on community-based adolescent mental health care and stigma reduction, highlighting intervention efficacy, implementation challenges, and translational potentials i
A multicenter randomized trial shows that middle meningeal artery embolization with n-butyl cyanoacrylate, adjunct to standard care, significantly reduces recurrence and reoperation rates in chronic subdural hematoma without increasing adve
This randomized clinical trial evaluated mirtazapine’s safety and efficacy for methamphetamine use disorder, revealing a modest but statistically significant reduction in methamphetamine use without unexpected adverse events, offering
In the EnTRIPS randomized trial, ultra-early remote ischemic postconditioning after successful endovascular thrombectomy was safe but did not significantly improve 90-day functional independence in acute ischemic stroke.
A randomized trial found that medically tailored meals and fresh produce were highly feasible after HF hospitalization, but neither strategy improved the primary 90-day heart failure utilization outcome versus usual care.
A large primary care trial found that a combined patient- and GP-focused deprescribing intervention safely reduced long-term proton pump inhibitor use more effectively than usual care or GP-only education.
In a phase 3 randomized withdrawal trial, ecopipam maintained tic improvement in pediatric Tourette syndrome over 24 weeks and showed a generally favorable safety profile without clinically meaningful weight, metabolic, or drug-induced move
Adding fovinaciclib to first-line aromatase inhibitor therapy significantly prolonged progression-free survival in hormone receptor-positive, ERBB2-negative advanced breast cancer with manageable toxicity and preserved quality of life.
A small randomized trial found that blocking IL-6 with tocilizumab showed promising, clinically meaningful trends for inflammation-related, hard-to-treat depression, especially for somatic symptoms, fatigue, anxiety, and quality of life, th
A randomized clinical trial found that electroacupuncture reduced pain more than sham treatment in postherpetic neuralgia, with benefits lasting at least one month and no major safety concerns.
A randomized trial found that rapid respiratory point-of-care testing did not reduce same-day antibiotic prescribing in primary care, though it was safe and may help when a virus is detected.
In ambulatory patients with obesity hypoventilation syndrome, automatically-adjusted noninvasive ventilation was as effective as manually adjusted NIV over 12 months and more cost-effective, offering a simpler path to treatment.
In a phase 3 trial, once-daily tavapadon improved motor symptoms in people with early Parkinson disease and was generally well tolerated, with nausea, headache, and dizziness as the most common side effects.
Psilocybin-assisted psychotherapy showed promising but inconclusive antidepressant effects in treatment-resistant depression, with notable acute adverse events and safety concerns.
In a 60-patient randomized trial, a digital therapeutic app delivering tinnitus education and CBT elements produced large, durable reductions in tinnitus-related distress over 16 weeks, with no serious safety concerns.
A randomized clinical trial found that dementia screening for family members of older adults did not improve quality of life or caregiver preparedness, nor did it increase depression or anxiety.
A 6-month personalized coaching program (SEE) significantly improved glaucoma medication adherence by 19.7% compared to standard education, reducing vision loss risk in a randomized trial of 235 patients.
This randomized clinical trial demonstrates that combining high-intensity circuit training with targeted sleep health interventions significantly improves objective sleep quality and cardiometabolic markers in young women, outperforming eit
