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Effect of Electroacupuncture on Postherpetic Neuralgia: A Randomized Clinical Trial
Neurologyelectroacupunctureneuropathic pain

Effect of Electroacupuncture on Postherpetic Neuralgia: A Randomized Clinical Trial

By MedXY|May 28, 2026

A randomized clinical trial found that electroacupuncture reduced pain more than sham treatment in postherpetic neuralgia, with benefits lasting at least one month and no major safety concerns.

Rapid Respiratory Point-of-Care Testing and Antibiotic Use in Primary Care: A Randomized Clinical Trial
Family Medicine & Nutritionantibiotic stewardshipPoint-of-Care Testing

Rapid Respiratory Point-of-Care Testing and Antibiotic Use in Primary Care: A Randomized Clinical Trial

By MedXY|May 26, 2026

A randomized trial found that rapid respiratory point-of-care testing did not reduce same-day antibiotic prescribing in primary care, though it was safe and may help when a virus is detected.

Effectiveness of Automatically-Adjusted vs Manually-Adjusted Noninvasive Ventilation in Obesity Hypoventilation Syndrome: A Randomized Clinical Trial
Internal Medicinenoninvasive ventilationobesity hypoventilation syndrome

Effectiveness of Automatically-Adjusted vs Manually-Adjusted Noninvasive Ventilation in Obesity Hypoventilation Syndrome: A Randomized Clinical Trial

By MedXY|May 21, 2026

In ambulatory patients with obesity hypoventilation syndrome, automatically-adjusted noninvasive ventilation was as effective as manually adjusted NIV over 12 months and more cost-effective, offering a simpler path to treatment.

Fixed-Dose Tavapadon for Early Parkinson Disease: A Randomized Clinical Trial
NeurologyDopamine Agonistneurology

Fixed-Dose Tavapadon for Early Parkinson Disease: A Randomized Clinical Trial

By MedXY|May 20, 2026

In a phase 3 trial, once-daily tavapadon improved motor symptoms in people with early Parkinson disease and was generally well tolerated, with nausea, headache, and dizziness as the most common side effects.

Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression: The EPISODE Randomized Clinical Trial
newspsilocybinpsychiatry

Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression: The EPISODE Randomized Clinical Trial

By MedXY|May 18, 2026

Psilocybin-assisted psychotherapy showed promising but inconclusive antidepressant effects in treatment-resistant depression, with notable acute adverse events and safety concerns.

A CBT-Based Mobile App Significantly Reduced Tinnitus Distress in a Sham-Controlled Randomized Trial
newsCognitive Behavioral Therapydigital therapeutic

A CBT-Based Mobile App Significantly Reduced Tinnitus Distress in a Sham-Controlled Randomized Trial

By MedXY|May 11, 2026

In a 60-patient randomized trial, a digital therapeutic app delivering tinnitus education and CBT elements produced large, durable reductions in tinnitus-related distress over 16 weeks, with no serious safety concerns.

Dementia Screening for Family Members: No Clear Benefit or Harm Found in Landmark Trial
Family Medicine & NutritionAlzheimer diseasecaregiver outcomes

Dementia Screening for Family Members: No Clear Benefit or Harm Found in Landmark Trial

By MedXY|Apr 24, 2026

A randomized clinical trial found that dementia screening for family members of older adults did not improve quality of life or caregiver preparedness, nor did it increase depression or anxiety.

Personalized Glaucoma Coaching Boosts Medication Adherence by 20%: SEE Program Trial Results
newsglaucomarandomized clinical trial

Personalized Glaucoma Coaching Boosts Medication Adherence by 20%: SEE Program Trial Results

By MedXY|Apr 23, 2026

A 6-month personalized coaching program (SEE) significantly improved glaucoma medication adherence by 19.7% compared to standard education, reducing vision loss risk in a randomized trial of 235 patients.

Beyond Exercise Alone: The Synergistic Power of Combined High-Intensity Circuit Training and Sleep Health Interventions
newscardiometabolic healthHigh-Intensity Circuit Training

Beyond Exercise Alone: The Synergistic Power of Combined High-Intensity Circuit Training and Sleep Health Interventions

By MedXY|Feb 23, 2026

This randomized clinical trial demonstrates that combining high-intensity circuit training with targeted sleep health interventions significantly improves objective sleep quality and cardiometabolic markers in young women, outperforming eit

Biopsychosocial Self-Management Superior to Standard Care for Reducing Disability in Acute Back Pain: Insights from the PACBACK Trial
Family Medicine & Nutritionlow back painrandomized clinical trial

Biopsychosocial Self-Management Superior to Standard Care for Reducing Disability in Acute Back Pain: Insights from the PACBACK Trial

By MedXY|Dec 30, 2025

The PACBACK randomized trial reveals that clinician-supported biopsychosocial self-management significantly reduces one-year disability in patients with acute low back pain at high risk of chronicity, whereas spinal manipulation alone offer

Tailored Weight Loss Interventions for Veterans with Serious Mental Illness: Efficacy and Implementation Insights from Recent RCT Evidence
Clinical Updatesrandomized clinical trialserious mental illness

Tailored Weight Loss Interventions for Veterans with Serious Mental Illness: Efficacy and Implementation Insights from Recent RCT Evidence

By MedXY|Dec 24, 2025

This review synthesizes evidence from a 2025 randomized clinical trial evaluating a tailored weight loss program, CoachToFit, for veterans with serious mental illness, highlighting its potential to improve weight outcomes via remote support

Combined Gastric Electrical Stimulation and Pyloroplasty Achieve Superior Symptom Relief in Refractory Gastroparesis
GastroenterologyGastroparesisrandomized clinical trial

Combined Gastric Electrical Stimulation and Pyloroplasty Achieve Superior Symptom Relief in Refractory Gastroparesis

By MedXY|Dec 21, 2025

A randomized clinical trial demonstrates that combining gastric electrical stimulation with pyloroplasty significantly outperforms pyloroplasty alone, providing superior symptom relief and reducing hospitalizations for patients with medicat

Digital Cognitive Behavioral Therapy for Generalized Anxiety Disorder: Evidence, Impact, and Future Directions
AIGeneralized Anxiety Disordermental health

Digital Cognitive Behavioral Therapy for Generalized Anxiety Disorder: Evidence, Impact, and Future Directions

By MedXY|Dec 21, 2025

Recent robust randomized trials demonstrate that smartphone-delivered digital cognitive behavioral therapy provides significant, sustained improvements in generalized anxiety disorder, overcoming key access barriers and highlighting its pot

Evaluating Serial Ketamine Infusions as Adjuncts in Inpatient Depression Care: Insights from the KARMA-Dep 2 Trial
newsKetaminemajor depression

Evaluating Serial Ketamine Infusions as Adjuncts in Inpatient Depression Care: Insights from the KARMA-Dep 2 Trial

By MedXY|Oct 24, 2025

The KARMA-Dep 2 trial reveals that serial ketamine infusions do not significantly outperform midazolam in reducing depressive symptoms among inpatients receiving usual psychiatric care, challenging assumptions about ketamine’s long-term ant

Evaluating Electromagnetic Network-Targeted Field Therapy for Post-Ischemic Stroke Disability: Insights from the EMAGINE Trial
Neurologydisability reductionischemic stroke

Evaluating Electromagnetic Network-Targeted Field Therapy for Post-Ischemic Stroke Disability: Insights from the EMAGINE Trial

By MedXY|Oct 21, 2025

The EMAGINE randomized clinical trial assessed low-intensity electromagnetic stimulation combined with rehabilitation in moderate to severe ischemic stroke patients. While safe, it did not yield statistically significant functional improvem

Optimizing Food Insecurity Interventions to Lower Blood Pressure: Insights from the Healthy Food First Trial
Cardiologyblood pressureFood insecurity

Optimizing Food Insecurity Interventions to Lower Blood Pressure: Insights from the Healthy Food First Trial

By MedXY|Oct 21, 2025

A factorial RCT in food-insecure adults with hypertension found that healthy food subsidies modestly reduced blood pressure compared with delivered food boxes, while lifestyle counseling and longer duration showed no added benefit.

Transcutaneous Peripheral Nerve Stimulation for Essential Tremor: Advancements from a 2024 Randomized Clinical Trial and Evolving Evidence
Clinical Updatesneuromodulationrandomized clinical trial

Transcutaneous Peripheral Nerve Stimulation for Essential Tremor: Advancements from a 2024 Randomized Clinical Trial and Evolving Evidence

By MedXY|Oct 21, 2025

AI-driven transcutaneous peripheral nerve stimulation (TPNS) shows significant improvements in upper limb function for essential tremor (ET), supporting a promising noninvasive treatment approach with manageable safety profile over 90 days.

Enhancing Lung Cancer Screening Uptake Through a Direct-to-Patient Digital Health Intervention: Insights from a Randomized Clinical Trial
AIrandomized clinical trial

Enhancing Lung Cancer Screening Uptake Through a Direct-to-Patient Digital Health Intervention: Insights from a Randomized Clinical Trial

By MedXY|Oct 21, 2025

A digital health program significantly increased lung cancer screening rates among high-risk individuals, underscoring digital tools’ potential to improve preventive care.

Single-Dose MM120 (Lysergide) Shows Promise in Treating Generalized Anxiety Disorder: Phase 2b RCT Results
Internal MedicineGeneralized Anxiety Disorderrandomized clinical trial

Single-Dose MM120 (Lysergide) Shows Promise in Treating Generalized Anxiety Disorder: Phase 2b RCT Results

By MedXY|Oct 21, 2025

A phase 2b trial reveals that single doses of MM120 produce dose-dependent reductions in anxiety symptoms in adults with moderate to severe generalized anxiety disorder, paving the way for phase 3 studies.

Heart Rate Variability Biofeedback in Substance Use Disorder: Emerging Evidence from a Randomized Clinical Trial and Contextual Review
Clinical Updatesrandomized clinical trialsubstance use disorder

Heart Rate Variability Biofeedback in Substance Use Disorder: Emerging Evidence from a Randomized Clinical Trial and Contextual Review

By MedXY|Oct 6, 2025

Second-generation heart rate variability biofeedback (HRVB) shows promise in reducing craving, negative affect, and substance use in adults with substance use disorder (SUD), supporting its potential as an adjunctive treatment in early reco

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