Section
This study evaluated the antidepressant effects of a Lactobacillus probiotic in overweight depressed patients with systemic low-grade inflammation, revealing no overall benefit but highlighting fecal formic acid as a potential biomarker for
A 3-month RCT demonstrates that multi-species probiotic supplementation improves vagal nerve function, gut microbiome composition, and sleep quality in patients with major depression, suggesting novel gut-brain axis interventions.
The AID-ME trial demonstrates that an AI-powered clinical decision support system significantly improves remission rates and accelerates symptom improvement in moderate to severe major depressive disorder.
A randomized clinical trial in Pakistan demonstrates that measurement-based care accelerates antidepressant treatment response and remission in major depressive disorder compared to standard care, underscoring its potential in low-resource
A randomized clinical trial demonstrates that personalized high-definition transcranial direct current stimulation (HD-tDCS) significantly improves mood in patients with moderate to severe depression, showing faster and comparable effect si
The Smart-T smartphone intervention significantly improves 7-day smoking abstinence at 26 weeks in low-income adults, outperforming the standard QuitGuide app when combined with nicotine replacement therapy.
A randomized trial demonstrates that graphic health warnings on little cigars and cigarillos significantly increase quitting intentions and related behaviors compared to FDA text-only warnings or no warnings, highlighting the need for enhan
A secondary analysis of four randomized trials reveals that additional behavioral therapy does not significantly improve opioid abstinence, retention, or functional outcomes when added to buprenorphine and medical management in opioid use d
This cluster-randomized trial evaluated an automated tobacco cessation intervention for parents in pediatric primary care, finding no significant increase in 1-year quit rates but notable improvements in treatment engagement and smoking red
A phase 4 randomized trial demonstrates that esketamine nasal spray monotherapy significantly reduces depressive symptoms in adults with treatment-resistant depression, offering a promising alternative to oral antidepressants.
A 4-week randomized trial shows that low-dose cannabidiol (CBD) may cause transient liver enzyme elevations in healthy adults, emphasizing the need for vigilance and further safety assessment of consumer CBD products.
A cluster randomized trial demonstrates that an electronic health record–integrated clinical decision support system increases naloxone prescriptions and opioid use disorder treatments in primary care but does not change diagnosis rates or
A pilot study demonstrates that a self-guided digital psychological intervention significantly reduces psychological distress and improves quality of life in patients with inflammatory rheumatic diseases, offering a scalable mental health s
A pilot randomized clinical trial demonstrates that a self-guided digital psychological intervention effectively reduces psychological distress and improves quality of life among patients with inflammatory rheumatic diseases.
A prospective UK Biobank study reveals that diets with higher pro-inflammatory potential, as measured by the Dietary Inflammatory Index, are significantly associated with increased risk of depressive and anxiety symptoms and disorders over
The MAGIC trial reveals midazolam’s superior efficacy over melatonin in reducing preoperative anxiety in children undergoing general anaesthesia, despite melatonin’s favorable safety profile. Challenges in recruitment and implications for f
Children with chronic physical illnesses face higher risks of mental health issues, partly due to early-life constraints on social and physical activities. Encouraging active play and social engagement may reduce these risks.
A comprehensive Swedish study reveals that patients with microscopic colitis face a significantly higher risk of developing psychiatric disorders such as depression and anxiety, underscoring the importance of holistic clinical management.
A multicenter trial assessing emotional and cognitive screening post-ischemic stroke found no improvement in societal participation at 1 year, though modest early benefits in anxiety and quality of life were noted.
Patients with hidradenitis suppurativa face a higher risk of first-time depression and anxiety, regardless of disease severity, highlighting the need for comprehensive psychiatric care.
