Highlight
1. Early psychosis patients show reduced grip strength associated with impaired well-being and global functioning.
2. Multivariate analysis reveals grip strength correlates with resting-state connectivity in sensorimotor, anterior cingulate cortex, and cerebellar regions.
3. These regions exhibit connectivity to the default mode network (DMN), linking motor function to broader cognitive and affective networks.
4. The observed relationships are more pronounced in the psychosis group, highlighting grip strength as a potential biomarker of neural network integrity and overall health.
