Section
This systematic review confirms that Neurofilament Light Chain (NfL) in blood and CSF effectively distinguishes behavioral variant frontotemporal dementia from psychiatric disorders, offering a powerful tool for early and accurate diagnosis
This large-scale case-control study examines how polygenic risk scores for suicide attempt intersect with clinical traits and environmental stressors. Findings indicate that genetic liability significantly correlates with aggression, depres
A landmark case-control study identifies significant associations between polygenic risk scores for suicide attempts and specific clinical traits, including aggression and depression severity, while also highlighting the interplay between g
A systematic review and meta-analysis of 12 clinical trials reveals that the quantity of preparation therapy—not post-dose integration—significantly predicts depressive symptom reduction in psychedelic-assisted therapy, highlighting the cri
A 46-year longitudinal study reveals that childhood ADHD traits significantly predict higher rates of physical health conditions, multimorbidity, and disability by middle age, mediated by modifiable risk factors like smoking, BMI, and psych
A retrospective study at Mayo Clinic reveals that children with a history of out-of-home placement experience 24% longer ED stays and double the odds of physical or pharmacological restraint during psychiatric emergencies compared to their
A Mayo Clinic study reveals that children with out-of-home placement histories face 24% longer ED stays and double the odds of being restrained during mental health crises, highlighting critical systemic disparities in pediatric emergency c
This population-based cohort study highlights how cumulative psychosocial stress across the life course significantly escalates the risk of neurovascular and neurodegenerative diseases, identifying depression as a critical target for interv
A landmark RCT demonstrates that adjunctive semaglutide significantly improves glycemic control and induces substantial weight loss in individuals with schizophrenia spectrum disorders treated with second-generation antipsychotics, potentia
This Swedish population-based study examines the complex relationship between depression and criminal convictions, revealing that neighborhood social structure and familial confounding significantly influence this association, with varying
A randomized clinical trial of the Relay peer-navigator intervention in New York City found no significant reduction in opioid-related adverse events compared to standard care, despite high patient satisfaction and the intervention’s
A cross-sectional study reveals that while federal disability surveys identify consistent populations across demographic groups, the underlying diagnoses are highly heterogeneous and age-dependent, with mental health and musculoskeletal con
A longitudinal study identifies that cumulative lifetime stress and systemic inflammation mediate nearly 50% of the mortality gap between Black and White adults, providing a biological link between structural inequity and premature death.
This large-scale individual participant data meta-analysis of 76,514 children reveals that prenatal maternal depression is significantly associated with increased risks of ADHD, ASD, and behavioral symptoms, independent of pre-pregnancy dep
A recent decision analytical model identifies duloxetine 120 mg as the most cost-effective treatment for moderate-to-severe fibromyalgia, providing superior clinical outcomes at a marginal cost increase compared to amitriptyline, particular
A geospatial analysis in Connecticut reveals that patients relying on public transit face travel times nearly four times longer than those with cars, with over 50% of areas lacking viable transit to methadone clinics, highlighting an urgent
The HEAL-HOA randomized clinical trial demonstrates that lay counselor-delivered telephone interventions using behavioral activation and mindfulness significantly and sustainably reduce loneliness and improve well-being among vulnerable, di
A comprehensive meta-analysis in JAMA Psychiatry reveals that current psychosocial interventions for schizophrenia and co-occurring substance use disorders offer negligible impact on symptoms and no significant effect on substance use reduc
A randomized clinical trial finds that a 6-week ketogenic diet provides modest antidepressant effects for treatment-resistant depression compared to a healthy control diet, though long-term clinical relevance and impact on secondary outcome
A randomized trial reveals that while automated decision support systems show marginal overall glycemic benefits in type 1 diabetes, personalized informative feedback significantly aids users with lower baseline knowledge. Success depends h
