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The VITALITY trial reveals that while high-dose vitamin D and calcium supplementation did not benefit all adolescents with HIV, it significantly improved bone density in those with baseline vitamin D insufficiency, providing a safe strategy
The POInT trial demonstrated that high-dose daily oral insulin does not prevent islet autoantibodies in infants at high genetic risk for type 1 diabetes. Despite its safety, the primary endpoint was not met, though genotype-specific interac
A post-hoc analysis of the Phase 3 JUVE-BASIS trial identifies key serum biomarkers, including CCL7, CCL18, and IL-6, that correlate with clinical response to baricitinib in JIA, suggesting potential pathways for personalized JAK inhibitor
A Phase 2 trial by the Children’s Oncology Group found that denosumab, despite its success in other bone-related conditions, failed to meet efficacy benchmarks for recurrent or refractory osteosarcoma, showing no objective responses i
This article examines the Planetary Health Diet Index for Children (PHDI-C), a tool designed to balance environmental sustainability with the unique nutritional requirements of growing children, highlighting its benefits for overall health
The Phase 3 VIITAL trial demonstrates that prademagene zamikeracel, an autologous gene-modified cellular sheet, significantly improves healing and reduces pain in patients with recessive dystrophic epidermolysis bullosa (RDEB), offering a t
A whole-population study from 2012–2023 reveals that while confirmed child maltreatment cases declined overall, disparities for Black children and female victims of sexual abuse remained stagnant or worsened, highlighting critical gaps in p
This large-scale study of 35,751 children characterizes ARFI phenotypes, revealing a 6.3% clinical prevalence and significant genetic heritability. Findings link ARFI to the ADCY3 locus and long-term neurodevelopmental difficulties, emphasi
A multi-center randomized clinical trial involving 257 youths found that adjunctive omega-3 fatty acids (1.5 g/d) did not outperform placebo in treating moderate-to-severe pediatric major depressive disorder, despite high adherence and conc
A multicenter study reveals that economic instability—specifically food insecurity—and poor social/community contexts significantly increase the odds of long COVID in US children and adolescents, highlighting the critical role of social det
A landmark Norwegian study reveals that umbilical cord LDL-C levels overlap significantly between FH and non-FH newborns, making birth screening unreliable. In contrast, LDL-C becomes highly discriminative after age one, suggesting that uni
The final report of the Hunter Outcome Survey (HOS) confirms that idursulfase treatment for Mucopolysaccharidosis II provides a 10-year survival benefit and a 57.9% reduction in mortality risk compared to untreated cohorts, alongside sustai
A Phase 1-2 study of tividenofusp alfa reveals a 91% reduction in CSF heparan sulfate and stabilized adaptive behavior in children with MPS II, overcoming the blood-brain barrier via transferrin receptor-mediated transport.
The INHALE-1 trial evaluated inhaled technosphere insulin in children. While it narrowly missed the primary HbA1c noninferiority margin, the study demonstrated improved patient satisfaction, reduced weight gain, and a favorable safety profi
A comprehensive BMJ umbrella review synthesizes evidence for ADHD interventions across the lifespan, confirming the efficacy of stimulants and non-stimulants in the short term while revealing a critical lack of high-certainty long-term data
A cluster-randomized trial of the ‘OurFutures Mental Health’ program demonstrates significant short-term reductions in anxiety symptoms among Year 8 and 9 students, highlighting the potential for scalable, digital, trauma-inform
The Phase I CHILD trial demonstrates that intramyocardial injection of neonatal cardiac progenitor cells during HLHS palliation is safe but does not improve right ventricular function at one year, despite promising signals in secondary clin
Recent evidence indicates that children conceived via frozen embryo transfer (FET) exhibit higher bone mineral content at age 7-10 compared to fresh transfer and natural conception, a difference primarily driven by higher birthweight. Conve
The BAT2 study reveals that the Basophil Activation Test (BAT) is the only biomarker capable of accurately predicting reaction severity to baked milk and the sensitivity threshold for fresh milk, offering a transformative tool for clinical
A comprehensive meta-analysis of over 260,000 infants confirms that nirsevimab significantly reduces respiratory syncytial virus (RSV) and lower respiratory tract infection (LRTI) hospitalizations and emergency department visits, providing
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