Long-Term Reality of Single-Ventricle Reconstruction: Shunt Choice, Tricuspid Regurgitation, and the Burden of Global Morbidity

Global morbidity remains exceptionally high, with 87% of SVR trial participants experiencing death or a major complication over 16 years of follow-up.
While overall outcomes did not differ significantly between the Right Ventricle-to-Pulmonary Artery Shunt (RVPAS) and the modified Blalock-Taussig-Thomas Shunt (mBTTS), a critical interaction with baseline tricuspid regurgitation was identified.
Participants with moderate-to-severe pre-Norwood tricuspid regurgitation had significantly worse outcomes and higher mortality when receiving an RVPAS compared to an mBTTS.
Prematurity and clinical site variation remain potent independent predictors of long-term outcomes in single-ventricle disease.

This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

Global morbidity remains exceptionally high, with 87% of SVR trial participants experiencing death or a major complication over 16 years of follow-up.
While overall outcomes did not differ significantly between the Right Ventricle-to-Pulmonary Artery Shunt (RVPAS) and the modified Blalock-Taussig-Thomas Shunt (mBTTS), a critical interaction with baseline tricuspid regurgitation was identified.
Participants with moderate-to-severe pre-Norwood tricuspid regurgitation had significantly worse outcomes and higher mortality when receiving an RVPAS compared to an mBTTS.
Prematurity and clinical site variation remain potent independent predictors of long-term outcomes in single-ventricle disease.

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