Our website uses essential cookies and, with your consent, additional cookies to measure performance and improve our services. Cookie Policy.
You can change your choice at any time.
A 66-year Japanese autopsy study reveals a significant reservoir of undiagnosed latent cancers, highlighting rising multiple primary cancer rates and substantial over-prevalence in prostate and thyroid tissues compared to clinical data, emp
A multisite study reveals that financial toxicity significantly reduces life satisfaction in cancer patients. However, hopefulness and social support act as critical mediators, suggesting that integrating psychosocial resilience training wi
The BENCHISTA study analyzes survival disparities in six childhood solid tumors across 27 countries, revealing that while stage at diagnosis influences outcomes, significant international survival variations persist for Ewing sarcoma and me
A population-based cohort study using SEER-21 data reveals that patients diagnosed with cancer during 2020 and 2021 experienced significantly lower 1-year cause-specific survival rates compared to prepandemic trends, resulting in an estimat
A large-scale federated study of 1.7 million European patients highlights significant variations in cancer survival and comorbidity profiles, emphasizing the role of real-world data and the OMOP-CDM framework in benchmarking oncological out
A massive cohort study of 2.2 million women reveals that ovarian cancer risk factors vary significantly by menopausal status and birth year. While early menarche and low parity remain universal risks, the protective benefits of breastfeedin
A massive cohort study reveals that colorectal adenoma recurrence risk is not static; high-grade dysplasia, villous histology, obesity, and sex-based factors exhibit distinct time-varying patterns, necessitating a shift toward personalized,
A large-scale study within the VA health system identifies Agent Orange exposure as a significant risk factor for acral melanoma, while highlighting distinct clinical profiles and a paradoxical inverse association with smoking compared to o
The final 9-year analysis of the CheckMate 238 trial confirms that adjuvant nivolumab provides a sustained recurrence-free survival advantage over ipilimumab in patients with resected high-risk melanoma, with 44% of patients remaining recur
The Phase 3 PATINA trial demonstrates that adding palbociclib to maintenance anti-HER2 and endocrine therapy significantly improves progression-free survival in HR+/HER2+ metastatic breast cancer patients, increasing the median duration fro
A secondary analysis of the CAPTAIN-1st trial reveals that adding camrelizumab to first-line chemotherapy significantly improves five-year overall survival in RM-NPC, with a 37.8% survival rate and notable benefits linked to rapid EBV DNA c
This article examines the clinical accuracy of Sentinel Lymph Node Biopsy for head and neck Merkel cell carcinoma, highlighting a significant false-negative rate and identifying risk factors that necessitate more personalized treatment stra
A 10-year follow-up of the ASPREE trial reveals that low-dose aspirin does not reduce cancer incidence in adults aged 70 and older, but is associated with increased cancer-related mortality, challenging long-held assumptions about aspirin&#
A comprehensive case-control study published in The Lancet Regional Health – Americas highlights how Intensity-Modulated Proton Therapy (IMPT) significantly reduces toxicities and improves quality of life for nasopharyngeal carcinoma
A case-control study comparing IMPT and IMRT for nasopharyngeal carcinoma shows that IMPT significantly reduces grade 2+ acute toxicities without compromising long-term survival or local-regional control, suggesting a superior therapeutic i
A massive 21-country study confirms that mammography screening has significantly shifted breast cancer detection toward earlier stages, contributing to a substantial decline in mortality across Europe, though treatment advances also play a
This study identifies activating EGFR L858R variants as the genetic basis for a syndrome featuring generalized acanthosis nigricans and lung nodules, highlighting the efficacy of EGFR inhibitors in treating both cutaneous and systemic manif
A large-scale multicenter study reveals that adherence to lymph node dissection guidelines significantly improves survival in early-stage lung adenocarcinoma patients with high-grade histologic patterns, while offering no significant benefi
This large-scale prospective cohort study identifies specific spleen length and volume thresholds that significantly increase the 5-year risk of hematologic malignancies and liver disease, providing a data-driven framework for clinical work
A multicenter study reveals significant discordance between clinician and patient assessments of skin cGVHD. While both correlate with survival, patient-reported outcomes are uniquely predictive of mortality in sclerotic disease, highlighti
Open language-specific specialty feeds and department pages.