Our website uses essential cookies and, with your consent, additional cookies to measure performance and improve our services. Cookie Policy.
You can change your choice at any time.
The Phase 3 GRACE trial demonstrates that relacorilant, a selective glucocorticoid receptor modulator, significantly maintains hypertension control in patients with Cushing’s syndrome without the safety concerns associated with non-selectiv
New research identifies TRIM28 as a critical E3 ubiquitin ligase that degrades IRP2, thereby suppressing iron uptake and preventing myocardial ferroptosis during ischemia/reperfusion injury. This pathway, activated by p55γ and the drug perh
This article details the SCORE2-HF risk model, a newly validated tool designed to estimate 10-year and 30-year heart failure risks in asymptomatic individuals, enabling earlier intervention and personalized cardiovascular care across divers
This clinical update synthesizes evidence on Roseburia inulinivorans, identifying it as a species-specific gut microbe that enhances muscle strength by modulating amino acid metabolism and skeletal muscle fiber types.
This review explores the development of WUSTL0717, a gut-restricted LXR agonist that mitigates liver injury in short bowel syndrome by leveraging the intestinal HDL-ApoA1 pathway without inducing systemic metabolic complications.
A longitudinal study of 2,260 participants confirms that oral glucose tolerance test (OGTT)-based surrogate indexes, particularly Gutt and Cederholm, are superior to fasting-only measures in predicting type 2 diabetes, providing high clinic
This phase 2 trial demonstrates that varenicline, a partial nAChR agonist, significantly reduces premature ventricular complexes and nonsustained ventricular tachycardia in post-myocardial infarction patients, offering a novel therapeutic t
A breakthrough study demonstrates that high-intensity interval training (HIIT) significantly enhances mitochondrial cristae density and surface area in men with type 2 diabetes, revealing remarkable plasticity in muscle ultrastructure despi
This large retrospective study of 820 patients reveals that restrictive ventricular physiology is the most common phenotype in cardiac amyloidosis. While preserved LV function offers better initial survival, the rate of progression to restr
The multicentre GOULASH trial reveals that high-energy nutrition in the early phase of acute pancreatitis does not improve outcomes and may increase risks of organ failure and pain relapse compared to a gradual caloric increase, leading to
A massive cohort study of 245,388 US adults reveals that 1 in 287 carries a familial hypercholesterolemia mutation. Despite high risks for premature heart disease, most carriers remain undertreated, with fewer than 20% of those with establi
The ACHIEVE-3 phase 3 trial demonstrates that orforglipron, a novel non-peptide oral GLP-1 receptor agonist, provides superior glycemic control compared to oral semaglutide in adults with type 2 diabetes, despite a higher frequency of gastr
Recent research identifies a specific molecular pathway—driven by HSF1 activation and increased cholesterol biosynthesis in smooth muscle cells—that explains why certain ACTA2 mutations predispose patients to premature atherosclerotic cardi
A landmark multicenter study of 156 patients reveals that acute eosinophilic myocarditis frequently presents without peripheral eosinophilia, carries a high risk of death or heart transplant, and requires early immunosuppressive therapy to
Patients with myocardial infarction due to isolated coronary artery ectasia face a significantly higher risk of recurrent MI and stent thrombosis compared to those without ectasia, highlighting the need for specialized long-term management.
A systematic review and meta-analysis of 64 randomized trials reveals that GLP-1 receptor agonists lead to significantly higher weight loss in women (10.9%) compared to men (6.8%), while maintaining consistent efficacy across various ages,
A large-scale retrospective study challenges the classic view of cardiac amyloidosis, revealing that while restriction is the dominant phenotype at diagnosis, nearly one-third of patients present with preserved function, and progression pat
This review synthesizes findings from a 21- **Compiling final edits** Now that I’ve structured the article, I’m focusing on the final touches, particularly the content for the “Highlights,” “Expert Commentary,&
This Mendelian randomization study reveals that coronary plaque burden significantly mediates the link between traditional risk factors and adverse events like myocardial infarction and heart failure, reinforcing the necessity of early prim
A large-scale study identifies restrictive physiology as the dominant phenotype in cardiac amyloidosis. While preserved function offers better survival, rapid progression to restriction underscores the importance of early diagnosis and moni
Open language-specific specialty feeds and department pages.