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In symptomatic HFpEF with atrial functional mitral regurgitation, sacubitril/valsartan improved exercise hemodynamics, peak VO2, symptoms, biomarkers, and stress-induced MR burden over 6 months versus standard care.
VHA study reveals only 30% of veterans hospitalized for AUD receive evidence-based medications during or shortly after hospitalization, with significant variation across hospitals and demographic factors influencing prescription rates.
意大利多中心研究发现，1升聚乙二醇抗坏血酸方案在住院患者结肠镜检查前肠道准备中，高质量清洁率显著优于2升和4升方案，且患者耐受性更好。
大规模国际研究发现甲状腺功能随年龄变化存在性别和碘状态差异。虽然多数人甲状腺功能稳定且TSH轻微升高，但任何变化模式均与全因死亡风险增加1.8-2.5倍相关，这对老年甲状腺健康管理具有重要临床意义。
An ex vivo human skeletal muscle study suggests that myosin ATPase inhibition with mavacamten normalizes excessive resting ATP consumption in HFrEF myofibres, identifying a mechanistically novel strategy to address peripheral metabolic inef
In Medicare patients undergoing femoropopliteal revascularization, drug-coated devices were not associated with higher long-term mortality, supporting the safety of paclitaxel-coated technology after years of regulatory concern.
In a pooled nonrandomized phase 3 analysis, monthly lerodalcibep reduced LDL-C by about 50% in heterozygous familial hypercholesterolemia, with similar efficacy across LDLR functional variant categories and broad attainment of guideline-bas
A new Hepatology study identifies an HSP72–PRDX6 pathway that restores PINK1/Parkin mitophagy, reduces hepatic steatosis, and worsens MASLD when disrupted in mice and hepatocytes.
Background Fontan palliation has transformed the prognosis of children born with single-ventricle heart disease, allowing...
Higher midlife cardiorespiratory fitness is associated with longer healthspan, fewer chronic diseases, and extended lifespan in men and women, based on a large observational cohort study linking clinical data to Medicare claims.
A recent randomized trial found PT modestly improved function over CBT in cLBP, but no second-stage treatment differences emerged for nonresponders. The study informs adaptive treatment strategies.
Community-based COPD patients with mild or single moderate exacerbations show higher future exacerbation risks and lung structural abnormalities, despite stable lung function decline rates.
A groundbreaking study introduces reverse CAR T cells to selectively deplete anti-ADAMTS13 autoreactive B cells in immune-mediated thrombotic thrombocytopenic purpura (iTTP), offering a novel, precise, and potentially safer therapeutic appr
A retrospective study reveals that the TSH-FT4 relationship is segmented, not log-linear, with implications for refining thyroid function test interpretation and reference intervals.
Study reveals significant time gaps between fingerstick glucose tests and insulin administration in hospitals, with nearly 30% of cases potentially receiving incorrect insulin doses due to changing glucose levels during delays.
Allogeneic hematopoietic stem cell transplantation offers a potential cure for blast-phase myeloproliferative neoplasms, with one-third of patients achieving long-term survival. Key factors influencing outcomes include TP53 mutations and pe
Conventional imaging-detected thyroid incidentalomas rarely prove malignant. A retrospective study found restrictive guidelines can sharply reduce unnecessary workup, though a small number of low-risk cancers may be missed.
Researchers have identified a genetic variant in the cubilin gene (CUBN, rs1801222) that significantly increases the risk of metformin-induced vitamin B12 deficiency, with carriers of the AA genotype experiencing deficiency up to twice as f
A randomized trial of 399 adults with long COVID fatigue found that fluvoxamine significantly reduced fatigue severity at 60 and 90 days compared to placebo, while metformin showed no benefit. The study represents a potential breakthrough i
Post-operative cardiologist evaluation after peri-operative myocardial injury was associated with fewer major cardiac events and lower 1-year mortality in high-risk non-cardiac surgery patients.
