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An ex vivo human skeletal muscle study suggests that myosin ATPase inhibition with mavacamten normalizes excessive resting ATP consumption in HFrEF myofibres, identifying a mechanistically novel strategy to address peripheral metabolic inef
In Medicare patients undergoing femoropopliteal revascularization, drug-coated devices were not associated with higher long-term mortality, supporting the safety of paclitaxel-coated technology after years of regulatory concern.
In a pooled nonrandomized phase 3 analysis, monthly lerodalcibep reduced LDL-C by about 50% in heterozygous familial hypercholesterolemia, with similar efficacy across LDLR functional variant categories and broad attainment of guideline-bas
A new Hepatology study identifies an HSP72–PRDX6 pathway that restores PINK1/Parkin mitophagy, reduces hepatic steatosis, and worsens MASLD when disrupted in mice and hepatocytes.
Background Fontan palliation has transformed the prognosis of children born with single-ventricle heart disease, allowing…
Higher midlife cardiorespiratory fitness is associated with longer healthspan, fewer chronic diseases, and extended lifespan in men and women, based on a large observational cohort study linking clinical data to Medicare claims.
A recent randomized trial found PT modestly improved function over CBT in cLBP, but no second-stage treatment differences emerged for nonresponders. The study informs adaptive treatment strategies.
Community-based COPD patients with mild or single moderate exacerbations show higher future exacerbation risks and lung structural abnormalities, despite stable lung function decline rates.
A groundbreaking study introduces reverse CAR T cells to selectively deplete anti-ADAMTS13 autoreactive B cells in immune-mediated thrombotic thrombocytopenic purpura (iTTP), offering a novel, precise, and potentially safer therapeutic appr
A retrospective study reveals that the TSH-FT4 relationship is segmented, not log-linear, with implications for refining thyroid function test interpretation and reference intervals.
Study reveals significant time gaps between fingerstick glucose tests and insulin administration in hospitals, with nearly 30% of cases potentially receiving incorrect insulin doses due to changing glucose levels during delays.
Allogeneic hematopoietic stem cell transplantation offers a potential cure for blast-phase myeloproliferative neoplasms, with one-third of patients achieving long-term survival. Key factors influencing outcomes include TP53 mutations and pe
Conventional imaging-detected thyroid incidentalomas rarely prove malignant. A retrospective study found restrictive guidelines can sharply reduce unnecessary workup, though a small number of low-risk cancers may be missed.
Researchers have identified a genetic variant in the cubilin gene (CUBN, rs1801222) that significantly increases the risk of metformin-induced vitamin B12 deficiency, with carriers of the AA genotype experiencing deficiency up to twice as f
A randomized trial of 399 adults with long COVID fatigue found that fluvoxamine significantly reduced fatigue severity at 60 and 90 days compared to placebo, while metformin showed no benefit. The study represents a potential breakthrough i
Post-operative cardiologist evaluation after peri-operative myocardial injury was associated with fewer major cardiac events and lower 1-year mortality in high-risk non-cardiac surgery patients.
An in-depth analysis of the FIBRONEER-IPF trial’s extended follow-up data, evaluating the efficacy and safety of the PDE4B inhibitor nerandomilast in reducing clinical events and mortality in patients with idiopathic pulmonary fibrosi
A prospective study highlights significant discrepancies between point-of-care and central laboratory sodium and potassium measurements in the ICU, revealing a 10.48 mmol/L limit of agreement for sodium and a widespread lack of physician aw
This review analyzes the complex factors influencing blood pressure management in older adults, highlighting how age, frailty, and digital health data shape clinician decisions and clinical inertia.
Long-term data from the FIBRONEER-IPF trial indicates that while nerandomilast did not significantly impact composite respiratory events, the 18 mg dose suggests a numerical reduction in mortality and maintains a favorable safety profile fo
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