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A randomized trial in high-risk adults with type 2 diabetes found that proactive nurse-led care reduced severe hypoglycemia by about 50%, while adding psychoeducation did not significantly improve outcomes further.
In two prospective cohorts of active, glucocorticoid-resistant thyroid eye disease, tocilizumab improved eye inflammation, proptosis, diplopia, and quality of life with acceptable safety, supporting IL-6 blockade as a promising second-line
The ELSA-Brasil study found that staging intermediate hyperglycaemia with fasting glucose plus 1-hour glucose better predicted type 2 diabetes than fasting glucose plus HbA1c, and a clinical risk score reduced unnecessary testing.
A large retrospective cohort shows that bilateral adrenal masses are usually benign and concordant, but asynchronous or discordant lesions identify a clinically important subgroup enriched for malignancy and pheochromocytoma.
CALERIE-2 post hoc analysis found that weight regain after caloric restriction can reverse improvements in insulin and IGF-1 signaling, while sustained weight loss preserves metabolic benefits and may lower biological aging markers.
In a pre-specified exploratory analysis of SURPASS-CVOT, tirzepatide reduced major kidney events versus dulaglutide in people with type 2 diabetes and cardiovascular disease, mainly by lowering new macroalbuminuria and slowing eGFR decline.
In a multi-institutional retrospective cohort, adrenalectomy for mild autonomous cortisol secretion was associated with lower mortality and less new-onset diabetes than nonoperative care, although sensitivity analysis weakened the survival
A 50-year follow-up of biliopancreatic diversion shows sustained weight loss and diabetes remission, but alarmingly high nutritional complications decades after surgery.
A large Dutch primary care cohort links subclinical hyperthyroidism to higher risks of atrial fibrillation, heart failure, and all-cause mortality, with particularly notable relative risks in younger adults and in patients with more strongl
A 7 T imaging and tracer study found that adults with type 1 diabetes have abnormal postprandial hepatic glucose uptake, blunted glycogen storage, reduced suppression of endogenous glucose production, and marked metabolic heterogeneity desp
New expert recommendations guide glucocorticoid dose reduction in pediatric classic CAH patients using crinecerfont, prioritizing normal growth while minimizing long-term steroid complications.
Registry data from 55,028 youths with type 1 diabetes show common LDL hypercholesterolemia, infrequent lipid-lowering therapy, and poor attainment of recommended LDL targets.
A large multi-ancestry study shows that publicly available polygenic risk scores improve prediction of type 2 diabetes onset and selected microvascular complications across major global ancestry groups.
A nationwide Swedish cohort study found marked geographic variation in type 1 diabetes incidence, with the strongest clustering linked to residential location during the first 5 years of life and higher risk in rural, forested, and agricult
In a pooled U.S. pregnancy cohort, maternal PFAS concentrations were not associated with a higher prevalence of gestational diabetes, and fasting glucose findings were largely null.
大规模国际研究发现甲状腺功能随年龄变化存在性别和碘状态差异。虽然多数人甲状腺功能稳定且TSH轻微升高，但任何变化模式均与全因死亡风险增加1.8-2.5倍相关，这对老年甲状腺健康管理具有重要临床意义。
In a 16-week randomized trial, adjunctive oral semaglutide improved effort-based decision-making in adults with major depressive disorder and overweight or obesity, suggesting a potential role for GLP-1 receptor agonism in reward-related dy
In a large single-center retrospective study, ACR TI-RADS implementation decreased follow-up thyroid ultrasound but did not reduce fine-needle aspiration, surgery, cancer yield, or overall costs.
In medullary thyroid carcinoma with biochemical persistent disease after surgery, an early postoperative calcitonin doubling rate of at least 0.3/year strongly identified patients at higher recurrence risk and may help tailor surveillance i
A large multinational cohort study found that teprotumumab use in thyroid eye disease was associated with higher risks of prediabetes, diabetes, and antidiabetes medication initiation over 5 years.
