Section
A retrospective study reveals that the TSH-FT4 relationship is segmented, not log-linear, with implications for refining thyroid function test interpretation and reference intervals.
Study reveals significant time gaps between fingerstick glucose tests and insulin administration in hospitals, with nearly 30% of cases potentially receiving incorrect insulin doses due to changing glucose levels during delays.
New study reveals uniform distribution of somatostatin and its receptors throughout the intestinal tract in both healthy individuals and type 2 diabetes patients, challenging previous assumptions about its role in diabetes pathophysiology.
A 36-year prospective study demonstrates that cumulative BMI burden from childhood to adulthood significantly elevates risks of metabolic multimorbidity, with distinct life-stage patterns and sex-specific vulnerabilities.
Phase 3a trial in Japan/Taiwan shows cagrilintide-semaglutide combination delivers superior weight loss (18.4%) versus semaglutide alone (11.9%) in adults with overweight/obesity ± type 2 diabetes, with comparable safety profiles dominated
A randomized trial found that a $80 monthly produce prescription did not significantly improve HbA1c levels or reduce healthcare utilization in diabetic patients at risk of food insecurity.
A Greenlandic study shows that Inuit with a specific sucrase-isomaltase gene variant have better glucose regulation on a Western diet compared to non-carriers, suggesting potential new diabetes treatments.
A real-world study validates the 2025 ATA thyroid cancer risk guidelines, showing significant patient reclassification and identifying a new ‘low-intermediate-risk’ group needing tailored management approaches.
A retrospective study of 670 papillary thyroid carcinoma patients validates the 2025 ATA risk stratification system, demonstrating a shift toward higher-risk classifications. The new ‘low-intermediate-risk’ class emerges as a di
A large-scale multinational study of over 1.2 million patients reveals that individual GLP-1 receptor agonists and SGLT2 inhibitors offer broadly similar cardiovascular protection in type 2 diabetes, challenging assumptions about meaningful
Researchers have identified a genetic variant in the cubilin gene (CUBN, rs1801222) that significantly increases the risk of metformin-induced vitamin B12 deficiency, with carriers of the AA genotype experiencing deficiency up to twice as f
A 16-week home-based trial combining testosterone with functional electrical stimulation and arm ergometry improved lean mass and corrected anemia in spinal cord injury patients, though aerobic capacity gains were not statistically signific
A nationwide cohort study of 466,462 infants reveals that maternal pregestational diabetes significantly increases the risk of delayed developmental milestones, with type 1 diabetes conferring the highest risk and female offspring showing p
A prospective study identifies exhaustion, head and neck discomfort, and body image concerns as independent predictors of poor emotional functioning in differentiated thyroid carcinoma patients. These findings highlight actionable targets f
A landmark population-based study spanning 2006-2020 in Stockholm, Sweden, reveals that biochemically confirmed primary hyperparathyroidism incidence increased by 52% while only half of affected patients received clinical diagnosis, highlig
A multicenter retrospective cohort study reveals that metabolic bariatric surgery in 162 adults with type 1 diabetes and obesity achieved 29.7% weight loss at one year, reduced insulin requirements by 57%, and significantly improved glycemi
A landmark Swedish cohort study of 95,490 patients reveals that semaglutide is associated with a 42% lower risk of worsening mental illness in people with depression and anxiety, while other GLP-1 receptor agonists show varied effects. The
A retrospective cohort study of 524,687 diabetic patients reveals that increasing severity of diabetic retinopathy correlates with significantly higher mortality risk, with proliferative DR patients showing a 128% increased hazard of death
A randomized trial of 205 pregnant women with gestational diabetes found that adjunctive flash glucose monitoring did not improve time-in-range glucose measurements compared to standard self-monitoring. However, the device was associated wi
A randomized crossover trial demonstrates that a dairy-enriched diet with high-protein breakfast and early daytime carbohydrate restriction significantly upregulates circadian clock genes (BMAL1, REV-ERBα, CRY1), improves glycemic metrics i
