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This review synthesizes population-level data on the eligibility for GLP-1RAs, SGLT2is, and nsMRAs, highlighting that over 60% of US adults meet indications for these transformative therapies.
A secondary analysis of the DANFLU-2 trial confirms that high-dose influenza vaccine significantly reduces cardiorespiratory hospitalizations in older adults with diabetes, with potentially enhanced benefits for those with longer disease du
A retrospective study highlights how 1-hour plasma glucose levels can identify early cardiometabolic risks in women with PCOS who appear to have normal blood sugar levels.
A prospective cohort study reveals that patients with low-risk papillary thyroid cancer experience similar quality of life outcomes at three years whether they choose active surveillance or immediate surgery, though those who crossover to s
A comprehensive analysis of the cAMP-driven pathogenesis of non-familial somatotroph adenomas, exploring how GNAS mutations and DNA damage response pathways dictate clinical behavior and therapeutic sensitivity in acromegaly.
A landmark study in Diabetes Care reveals that soluble urokinase plasminogen activator receptor (suPAR) mediates over half of the increased risk for adverse cardiovascular outcomes in patients with diabetes and coronary artery disease, surp
This review analyzes multinational data showing a significant decline in cardiovascular mortality among diabetes patients, alongside a concerning rise in dementia-related deaths and the emergence of cancer as a leading cause of mortality in
This review explores how adipocyte-derived small extracellular vesicles (sEVs) use surface-bound adiponectin to protect the heart, and how diabetes-induced GRK2 upregulation disrupts this vital signaling pathway, leading to ischemic heart f
The PACE-It pilot program demonstrates that integrating health and social care via multidisciplinary teams and technology significantly improves glycemic control, lipid management, and patient activation for individuals with complex needs,
A pilot randomized controlled trial demonstrates that the PACE-It program, an integrated multidisciplinary team utilizing technology-assisted communication, significantly improves glycemic control, lipid management, and patient activation i
This review synthesizes evidence comparing SGLT2 inhibitors and GLP-1 receptor agonists, highlighting a significant reduction in chronic kidney disease and acute kidney injury risks associated with SGLT2i initiation.
This article summarizes the updated clinical care pathway for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), highlighting new diagnostic nomenclature, risk stratification tools, and the integration of the first FDA-approv
A longitudinal analysis from the SWAN study indicates that women treated with levothyroxine for hypothyroidism do not face a higher risk of cardiovascular events compared to those without thyroid disease, providing clinical reassurance for
A randomized cross-over trial reveals that empagliflozin enhances beta cell function and insulin sensitivity more effectively than titrated insulin, suggesting benefits beyond simple glucotoxicity relief.
A prospective study of over 700,000 newborns demonstrates that LC-MS/MS significantly improves the positive predictive value (PPV) of CAH screening compared to traditional RIA, identifying specific steroid ratios that offer 100% PPV and red
This review analyzes the lifestyle patterns of pregnant women with type 1 diabetes, synthesizing findings from the ENDIA study with recent evidence on nutritional adequacy, islet autoimmunity, and the molecular mechanisms of metabolic compe
The Phase 3 GRACE trial demonstrates that relacorilant, a selective glucocorticoid receptor modulator, significantly maintains hypertension control in patients with Cushing’s syndrome without the safety concerns associated with non-selectiv
This emulation study applies SELECT trial data to over 600,000 individuals, suggesting that GLP-1RAs could significantly reduce 10-year cardiovascular risk in high-risk obese populations without existing disease, offering a potential 22% re
This review synthesizes findings from a national multicenter study identifying that hyperghrelinemia is a specific biomarker for Prader-Willi Syndrome, whereas other rare neurodevelopmental disorders exhibit normal ghrelin levels despite se
This review details the development and psychometric validation of the TCQOLI, a novel thyroid-cancer-specific utility measure designed to provide precise preference-based health state valuations for clinical research and policy-making.
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