Association of the Primary Aldosteronism Severity Classification with Lateralization and Treatment Outcomes: A Comprehensive Review

The Primary Aldosteronism Severity Classification (PASC) significantly correlates with AVS-defined lateralization, with severity reflecting increasing unilateral aldosterone excess.
Surgical and medical treatment outcomes vary by PASC severity; higher severity is associated with lower rates of complete clinical success despite similar biochemical remission rates.
Emerging hormonal biomarkers (e.g., metanephrine, androstenedione) and imaging modalities (68Ga-pentixafor PET/CT) show promise in enhancing AVS accuracy and subtype diagnosis.
Integration of PASC with AVS results may guide individualized diagnostic and therapeutic strategies, optimizing patient outcomes in PA.

This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

The Primary Aldosteronism Severity Classification (PASC) significantly correlates with AVS-defined lateralization, with severity reflecting increasing unilateral aldosterone excess.
Surgical and medical treatment outcomes vary by PASC severity; higher severity is associated with lower rates of complete clinical success despite similar biochemical remission rates.
Emerging hormonal biomarkers (e.g., metanephrine, androstenedione) and imaging modalities (68Ga-pentixafor PET/CT) show promise in enhancing AVS accuracy and subtype diagnosis.
Integration of PASC with AVS results may guide individualized diagnostic and therapeutic strategies, optimizing patient outcomes in PA.

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