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Tomatine, a natural compound incorporated into mRNA vaccine nanocarriers, significantly enhances antigen expression and innate immune activation, boosting adaptive immunity against tumors and SARS-CoV-2, underscoring its potential as a vers
This study elucidates drug resistance patterns and genotype-phenotype correlations in multidrug-resistant Mycobacterium tuberculosis strains from Hainan Island, China, revealing implications for tailored MIC-based therapies.
This study reveals that over 80% of tuberculosis cases among South African household contacts are asymptomatic and often missed by symptom and chest X-ray screening, highlighting the need for improved diagnostic strategies to detect subclin
A comprehensive 50-state survey reveals widespread conspiratorial thinking among American adults linked to demographic factors and COVID-19 vaccine hesitancy, with implications for public health strategies.
The AMALFI trial evaluates remote screening for asymptomatic atrial fibrillation in older adults to improve detection, anticoagulation use, and reduce stroke risk, with findings pending follow-up at 2.5 and 5 years.
The AMALFI trial demonstrates that remote, mail-based 14-day ECG patch screening modestly increases long-term atrial fibrillation detection and anticoagulation use in older adults at stroke risk, with no observed reduction in stroke at 2.5
This study compares five dementia risk indices using data from the HUNT study, revealing CogDrisk as the most accurate predictor, though none outperformed a demographics-only model including age and education.
Higher moderate-to-vigorous physical activity slows p-tau181 increase, a marker of Alzheimer’s pathology, but elevated p-tau181 diminishes exercise-related cognitive benefits in older adults.
This qualitative UK study explores older patients’ perspectives on shared decision making for treatment escalation during acute hospital deterioration, highlighting the need for patient autonomy, education, and adaptable clinical appr
This multicentre longitudinal cohort study reveals significant HIV prevalence and incidence among adults aged 40 and older in sub-Saharan Africa, highlighting age, gender, education, and rural residency as critical factors influencing HIV r
This prospective Spanish cohort study reveals that moderate-to-vigorous physical activity enhances intrinsic capacity in older adults, while sedentary behavior impairs it, underscoring the role of active lifestyles in promoting healthy agei
A 30-year birth cohort study reveals that life-course factors, especially modifiable markers like BMI, blood glucose, and blood pressure, significantly influence the buildup of chronic diseases across eight organ systems, yet much remains u
This analysis reveals stable dementia risk fractions despite changing risk profiles over 15 years in Australia, highlighting greater modifiable risk among low-income groups and males, with depression emerging as a leading factor in mid-life
The GBD 2023 Study integrates data from 204 countries to reveal shifting global mortality patterns, emphasizing the impact of COVID-19, declining vaccine-preventable deaths, and rising non-communicable diseases, highlighting critical areas
Higher adherence to the planetary health diet is linked with a 32% reduced risk of type 2 diabetes and significantly lower greenhouse gas emissions, supporting its role in preventing diabetes and promoting sustainability.
Higher adherence to the Planetary Health Diet Index, reflecting environmentally sustainable plant-based eating patterns, is strongly associated with reduced type 2 diabetes risk in UK Biobank participants, comparable or superior to other es
The Hospital Frailty Risk Score (HFRS) predicts length of stay, mortality, and costs across all adult age groups in England, with stronger effects in older adults, supporting broader clinical use beyond the elderly.
The INTERSTROKE study reveals how age modifies the relationship between vascular risk factors and acute stroke, highlighting age-specific prevention priorities to reduce stroke burden globally.
A comprehensive study spanning 47 countries reveals changing suicide mortality rates among adults aged 65+, highlighting method-specific risks and projecting future trends amid global population ageing.
A population-based study reveals that midlife exposure to air pollutants such as nitrogen dioxide and particulate matter is associated with cognitive decline and brain structural alterations by age 69-71, highlighting long-term neurological
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