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A systematic review of 347 randomized trials reveals that non-industry-sponsored trials lag significantly behind industry counterparts in registration and results publication, with nearly one-third of all trials discontinued prematurely due
A 47-year study shows physical capacity peaks in the late 20s–30s and accelerates downward from about age 40 — but regular exercise, started at any age, can meaningfully delay decline.
The DANFLU-2 trial found that while high-dose influenza vaccines significantly reduced influenza-specific hospitalizations in older adults, they did not reach statistical significance for the combined primary endpoint of influenza or pneumo
This review examines the safety and effectiveness of electronic cigarettes as aids to quit smoking, showing increased abstinence rates compared to traditional therapies and no significant serious adverse events reported.
Updated Cochrane review finds nicotine e-cigarettes increase smoking cessation success compared to NRT and non-nicotine e-cigarettes, with no clear difference in serious adverse events.
A large network meta‑analysis confirms HPV vaccines effectively reduce CIN2+ and anogenital warts, with no major safety concerns.
A national cohort study from England and Wales found two-thirds of infants born <32 weeks’ gestation had ≥1 hospital admission before age 2, with lower gestational age and neonatal morbidities (BPD, severe NEC, brain injury) substantiall
This review synthesizes data on mifepristone availability at community pharmacies in BC, highlighting geographic coverage, dispensing gaps, and disparities influencing timely access to medication abortion.
A large Ontario cohort study links early-life exposure to the Great Chinese Famine with higher adult risks of type 2 diabetes and hypertension among Chinese immigrants, while cardiovascular hospitalization was not increased; methodological
This clinical trial evaluated monthly grocery vouchers for improving diabetes control in food-insecure patients, finding increased self-reported fruit and vegetable intake but no significant HbA1c improvement.
This review synthesizes global evidence, including meta-analyses, showing that school feeding programs modestly improve math achievement, enrollment, and growth metrics in socioeconomically disadvantaged children, with limited effects on re
A phase 2a human challenge trial found a nucleoside‑modified mRNA influenza vaccine provided complete protection against symptomatic and febrile A/H1N1 infection versus unvaccinated controls and reduced viral load versus control and QIV, wi
A randomized trial of 20,330 girls 12–16 years shows one dose of bivalent or nonavalent HPV vaccine prevents persistent HPV16/18 infection as effectively as two doses over 5 years, with high effectiveness and no safety signals.
A Swedish cohort study of 10,222 men linked adolescent blood pressure to coronary atherosclerosis by CCTA ~40 years later; higher systolic BP in adolescence, even in the ‘elevated’ range, was associated with greater odds of severe (>50%)
A multicentre phase 1 trial in healthy US adults found nOPV1 and nOPV3 were well tolerated and induced robust homotypic neutralising antibody responses with shedding profiles similar to Sabin monovalent OPV, supporting progression to phase
A 13-year national cohort shows that combined healthy lifestyles and favourable social determinants substantially increase years lived independently; men gain more from behavioural change while women gain more from improved social condition
A life cycle assessment found SAVR produces roughly double the carbon footprint of transcatheter aortic valve replacement (TAVR), with postoperative ICU and ward care as the main drivers. Results highlight opportunities to decarbonize cardi
A life cycle assessment found SAVR emits ~620–750 kg CO2e per case—roughly double OR- or cath-lab TAVR (~280–360 kg CO2e). ICU length of stay and postoperative care were the dominant contributors, highlighting targets for low-carbon periope
In a phase 2a human challenge, high‑dose daily mosnodenvir substantially reduced DENV‑3 RNA burden versus placebo without serious adverse events, but treatment‑associated NS4B viral mutations emerged, highlighting efficacy and resistance co
Multi-objective optimization in the EPIC cohort shows that modest gains in adherence to the EAT‑Lancet diet, increased plant species richness, and substitution of ultra‑processed foods with minimally processed foods can raise nutrient adequ
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