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A large U.S. study found that a contrast sensitivity score of 1.60 logCS marks the point where older adults are more likely to experience everyday vision disability, even when standard visual acuity may seem acceptable.
In the HUNT Study, higher midlife waist-to-height ratio and BMI predicted higher late-life plasma p-tau217 and biomarker-verified Alzheimer dementia, whereas higher adiposity in late life was associated with lower biomarker levels and lower
A small randomized trial found that blocking IL-6 with tocilizumab showed promising, clinically meaningful trends for inflammation-related, hard-to-treat depression, especially for somatic symptoms, fatigue, anxiety, and quality of life, th
A survey study found three distinct patient preference patterns for anticoagulation after hip or knee replacement: clot-prevention focused, balanced, and cost-focused. These differences may help personalize postoperative blood thinner choic
A survey study found three distinct patient preference patterns for anticoagulation after hip or knee replacement, highlighting the importance of shared decision-making based on clot risk, bleeding risk, and cost.
ACP warns that private equity in health care can raise costs, weaken clinical autonomy, and affect access and quality, calling for stronger transparency, oversight, and protections for physicians and patients.
A new multimodal study links regular physical activity to lower chronic pancreatitis risk and identifies muscle-derived extracellular vesicles as a plausible mechanism limiting pancreatic inflammation, fibrosis, and ferroptosis.
A large multi-cohort genome-first study found similar prevalence of pathogenic FH variants across ancestries, but more VUSs and greater LDL-C and myocardial infarction risk among African ancestry individuals, highlighting likely underclassi
A large Danish genetic study suggests recurrent CNVs and polygenic scores provide complementary psychiatric risk information, with polygenic scores often identifying more at-risk individuals and potentially modifying CNV-associated risk.
A qualitative VA study found that COVID-19 reduced trainee learning opportunities and heightened safety concerns, yet trainees contributed substantially to care delivery, telehealth expansion, patient support, and local pandemic planning.
A 2010-2023 analysis found that CMS enforcement against Medicare Advantage plans was highly variable, usually limited to modest monetary penalties, and more common among lower-rated contracts serving more socially vulnerable beneficiaries.
The 2024 EBMT activity report marks a major cellular therapy milestone, showing record allogeneic HCT, continued CAR-T expansion, and persistent disparities in donor use, pediatric activity, and country-level access.
A cancer program quality improvement initiative reached a 100% smoking-status ask rate through an electronic hard stop, but assistance for identified smokers remained inconsistent, underscoring the implementation gap between screening and e
Older stroke patients treated in rural hospitals received less inpatient rehabilitation and more skilled nursing facility care than urban patients, with fewer days at home over 1 year but similar overall mortality.
A multicomponent emergency department workflow using screening, electronic prompts, and discharge decision support significantly increased naltrexone prescribing for patients with alcohol-related diagnoses.
A large pooled US cohort study found that COPD substantially reduces life expectancy, even among never-smokers, with years of life lost increasing progressively from GOLD stage 1 through stage 4.
A national SRTR analysis shows that transplant center geography still strongly influences effective donor access after CAS implementation, and the 2026 proximity-weighted amendment is likely to widen disparities, especially for biologically
Portable HEPA air cleaners plus motivational interviewing improved symptoms and quality of life in smokers with COPD by reducing indoor particulate matter, though lung function and exacerbations did not significantly change.
A nationwide French cohort found earlier diagnosis, falling relapse rates, and major treatment shifts in AQP4+NMOSD and MOGAD, with rituximab linked to lower disability risk in AQP4+NMOSD and overall milder disability trajectories in MOGAD.
Wearable accelerometer sleep-wake patterns were linked to later dementia risk in two UK cohorts and modestly improved prediction beyond age and standard risk factors.
