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This study explores how heavy menstrual bleeding affects physical, psychological, social, and functional aspects of life, revealing extensive quality of life impairment beyond just blood loss.
This prospective cohort study investigates how fructose-containing beverages and foods, including sugar-sweetened beverages, fruit juices, and whole fruits, consumed from childhood through adulthood influence hypertension risk, highlighting
Pharmacy interventions on ED medication orders increased as clinicians spent more time on shift. The association persisted across roles and shift types, suggesting fatigue-related risks but varying by site.
A qualitative study across 12 Colorado hospitals found that an EHR-embedded OUD intervention improved awareness but still faced stigma, inconsistent messaging, limited addiction expertise, and workflow barriers to MOUD initiation.
In over 1 million US veterans, the 2024-2025 COVID-19 vaccine was associated with fewer COVID-19-related cardiovascular events, with the strongest benefit in adults over 75 and those with comorbidities.
A multicenter randomized trial found that 4-week multimodal prehabilitation added to ERAS reduced 90-day complications after spinal fusion in adults aged 75 years or older.
A validation study suggests current liver fibrosis screening criteria are too broad. A refined risk-based approach reduced eligibility from 60–76% to 10–22% of adults while improving the yield of elevated liver stiffness and predicting futu
The POINTER Imaging study found no overall brain biomarker changes from a structured lifestyle intervention, but participants with lower baseline hippocampal volume showed greater cognitive benefit, suggesting imaging may help identify who
Time-restricted eating performed similarly to individualized dietetic guidance for short-term HbA1c change in adults at risk of type 2 diabetes, but non-inferiority was not confirmed at 12 months. Benefits were small, and adverse events wer
A large real-world study found that public implementation of intermittently scanned continuous glucose monitoring in insulin-treated type 2 diabetes was linked to better HbA1c, fewer acute diabetes hospitalizations, shorter stays, and lower
In a nationwide Finnish cohort, earlier ADHD diagnosis was linked to better school performance, more academic progression, and less dropout than diagnosis closer to age 16, especially before educational track selection.
Intensive oseltamivir chemoprophylaxis for ≥70% of nursing home residents within 2 days of influenza outbreak reduces hospitalization risk, underscoring prompt antiviral intervention as a critical outbreak control strategy.
A nationwide Dutch study suggests pregnancy in women with peripheral vascular malformations is frequently complicated by symptom progression and postpartum hemorrhage, with venous thromboembolism concentrated in extensive lower-extremity ma
A large U.S. study found that even PM2.5 levels below current federal standards were linked to higher hypertension hospitalization risk in older adults, especially among women and some regional and socioeconomic groups.
Among more than 26 million older U.S. adults, even PM2.5 levels below current standards were linked to higher hypertension hospitalization risk, suggesting no clearly safe low-exposure threshold.
Higher blood IL-6 levels were strongly linked to nine cardiovascular and mortality outcomes in nearly 60,000 adults, supporting IL-6 as an important inflammatory marker and potential prevention target.
A randomized trial found that medically tailored meals and fresh produce were highly feasible after HF hospitalization, but neither strategy improved the primary 90-day heart failure utilization outcome versus usual care.
Population-based testing for breast cancer pathogenic variants identified many women who would not have been flagged by clinical or polygenic risk models, supporting its role in risk-based screening.
A genome-first study found similar rates of pathogenic FH variants in African and European ancestry groups, but uncertain variants were more common and potentially more harmful in African ancestry individuals, highlighting the need for more
A large Tokyo case-crossover study found that short-term exposure to low ambient temperature increases acute heart failure admissions, especially in older adults, while patients with hypotensive presentations may be more vulnerable to heat.
