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CALERIE-2 post hoc analysis found that weight regain after caloric restriction can reverse improvements in insulin and IGF-1 signaling, while sustained weight loss preserves metabolic benefits and may lower biological aging markers.
A population-based study of older adults with metastatic NSCLC found that fewer than half received systemic treatment, with only slight improvement over time. Oncology referral and biomarker testing were strongly linked to treatment, while
A large SEER-Medicare study found that fewer than half of older adults with metastatic NSCLC received systemic therapy, with only modest improvement from 2006 to 2021. Specialist referral and biomarker testing were strongly linked to treatm
A national analysis of US office visits found that obesity counseling remains uncommon, with only 40.1% of visits including any counseling and 12.2% including weight, diet, and exercise advice together.
In this post hoc analysis of a large randomized pregnancy trial, aspirin’s effects on preterm birth and perinatal mortality were not meaningfully modified by gestational age at initiation or measured adherence.
In nearly 483,000 UK Biobank participants, sarcopenia, low grip strength, and slow walking pace were associated with higher risks of incident stroke and poorer survival after stroke.
A large multi-ancestry study shows that publicly available polygenic risk scores improve prediction of type 2 diabetes onset and selected microvascular complications across major global ancestry groups.
A large South Korean study reveals critical illness survivors face severe socioeconomic consequences, with 27.6% experiencing income decline and 12.3% job loss within a year, disproportionately affecting high-income households despite unive
A French study reveals African ancestry significantly increases relapse risk in iTTP patients treated with rituximab. Key risk factors include male sex and prior relapses, with implications for personalized monitoring strategies.
A molecular epidemiology study in Durban found that casual community contact, not only household or named contacts, accounted for a substantial share of drug-resistant tuberculosis transmission.
A large multicenter study found that MIPS measure 191 captures high cataract surgery success rates but excludes many patients and may require case-mix adjustment to support fair surgeon comparisons.
In a large TriNetX retrospective cohort, prescribed NSAID use was associated with a lower subsequent risk of AMD, including both non-exudative and exudative disease, though residual confounding limits causal inference.
A narrative review suggests HPV self-sampling is acceptable and potentially practice-changing for transmasculine and nonbinary people who are often underscreened for cervical cancer.
A nationwide Swedish cohort study found marked geographic variation in type 1 diabetes incidence, with the strongest clustering linked to residential location during the first 5 years of life and higher risk in rural, forested, and agricult
Among older U.S. adults with dementia, non-Hispanic Black and Hispanic individuals were significantly less likely than non-Hispanic White individuals to receive a timely diagnosis, with education and neighborhood affluence explaining much o
A matched difference-in-differences study found that the Oncology Care Model did not increase systemic therapy initiation overall and was associated with lower treatment initiation and lower spending in poor-prognosis cancers.
During Boston’s devastating 1955 polio epidemic, Massachusetts General Hospital trainees conducted groundbreaking patient research while providing round-the-clock care in iron lung wards – a striking contrast to trainee roles during C
A prospective study found frequent medium-to-high ergonomic risk and measurable postoperative pain among otolaryngology surgeons, highlighting modifiable occupational hazards in routine head and neck surgery.
A large Medicare cohort found low 5-year operative recurrence after groin hernia repair overall, with laparoscopic repair showing the lowest adjusted risk and robotic-assisted repair offering no recurrence advantage despite rapid uptake.
A U.S. mortality analysis from 1999 to 2020 found increasing deaths from status epilepticus after 2007, with marked disparities by age, sex, race/ethnicity, and region.
