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Mass azithromycin administration to both infants and older children reduced infant mortality more than treating infants alone, with potential spillover benefits from treating older siblings.
A multicenter study in Japan found that adequate daptomycin dosing significantly improves clinical outcomes in pediatric patients, while adverse events can occur regardless of renal function.
Perinatal antibiotic exposure in preterm infants disrupts gut microbiota composition, increasing pathogenic bacteria and reducing beneficial species, with implications for infection risk and the protective role of breastfeeding.
Minority children and those from lower socioeconomic backgrounds receive significantly more and broader-spectrum antibiotics for pneumonia during hospitalization than non-Hispanic White counterparts, contrary to outpatient trends.
This article explores the causes, implications, and prevention strategies for early puberty in children, supported by clinical insights and expert recommendations.
Explore the differences, uses, and safety of ibuprofen and acetaminophen for managing fever effectively.
Oral iptacopan provides sustained haemolysis control and improved haemoglobin in PNH patients over 48 weeks, with a favorable safety profile, supporting its role as a new therapeutic option.
A phase 4 trial in The Gambia finds that maternal Tdap-IPV vaccination is safe and provides early infant protection, but modestly blunts immune responses to whole-cell pertussis vaccines without compromising overall immunogenicity.
A phase 3 trial demonstrates prademagene zamikeracel significantly accelerates healing and reduces pain in large, chronic RDEB wounds, offering a promising gene therapy with a favorable safety profile.
A large randomized trial in Zimbabwe found that trimethoprim–sulfamethoxazole prophylaxis during pregnancy did not significantly increase birth weight or reduce adverse outcomes.
A multicenter phase 3 trial finds inhaled isoflurane as effective as intravenous midazolam for sedation in mechanically ventilated children, with added benefits of reduced opioid use and faster extubation.
Sweetener intake, especially aspartame and sucralose, is linked to increased risk of early puberty in genetically predisposed children, with notable sex-specific differences
A comprehensive Danish cohort study finds no evidence linking early childhood aluminum-adsorbed vaccines to increased risks of autoimmune, allergic, or neurodevelopmental disorders, supporting vaccine safety.
The FDA has approved Sephience, an oral therapy for phenylketonuria (PKU), offering a novel treatment option for both children and adults with this rare metabolic disorder.
EMA endorses sebetralstat, the first oral on-demand therapy for hereditary angioedema, following positive results from the KONFIDENT phase 3 trial, offering a more convenient and rapid treatment option for acute attacks.
Norovirus vaccines show promise in clinical trials, but scientific and logistical challenges remain. No approved vaccine exists yet, though novel approaches, including oral pills, are advancing development.
A multicenter US study highlights the devastating burden of influenza-associated acute necrotizing encephalopathy in children, with high mortality and disability rates despite aggressive therapy, underscoring the urgent need for prevention
Stronger leg muscles are linked to significantly lower risk of metabolic syndrome in children and adolescents with obesity, highlighting the importance of muscular fitness in paediatric metabolic health.
Once-weekly lonapegsomatropin (Skytrofa) is now FDA-approved for adult growth hormone deficiency, offering a more convenient alternative to daily injections with demonstrated efficacy and safety.
Research highlights increased birth defect risks linked to TMP-SMX use in pregnancy, urging cautious antibiotic selection for treating UTIs.
Open language-specific specialty feeds and department pages.