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In a cohort of 50 individuals with CHARGE syndrome, GI problems affected 64% and constipation 48%, with constipation associated with lower PedsQL GI scores and greater comorbidity; younger patients had more diverse GI issues while older pat
DB-OTO, a hair-cell-specific dual-AAV gene therapy encoding full-length human otoferlin, achieved dose-dependent and sustained auditory restoration in OTOF-deficient mice, supporting an ongoing Phase I/II pediatric trial.
A 5.5-year prospective cohort found lower-extremity apophysitis common in schoolchildren (1265 episodes in 1670 children), median symptom duration 3–4 weeks, and higher risk with soccer, handball, basketball and jump gymnastics but not from
The FAIR systematic review and consensus synthesizes evidence on prevention strategies and modifiable risk factors for upper‑extremity injury in female/woman/girl athletes, highlighting shoulder exercise programmes and key research gaps.
A case-crossover study of 51 boys (8–12 y) shows higher ear and skin temperatures during hot summer football training (≥25 °C), with no change in hydration by urine density and no severe heat illness noted. Findings highlight risk threshold
Favism, a hereditary enzyme deficiency causing red blood cell breakdown upon exposure to certain triggers like fava beans, is preventable with proper diagnosis and management. This article explores its clinical features, diagnosis, treatmen
This study identifies clinical and demographic factors associated with positive blood cultures in hospitalized children across nine African and Asian countries, aiming to improve diagnostic stewardship amidst resource constraints.
This article reviews two types of flu vaccines for children—live attenuated and inactivated—over 20 years, demonstrating both provide meaningful protection and highlighting improvements that have enhanced their effectiveness.
This study elucidates how copy number variants (CNVs) contribute to variability in child psychopathology and cognitive function, highlighting specific CNV regions and aggregated genetic risk affecting attention and cognitive domains during
This study identifies reduced neural efficiency during threat processing as a biomarker in pediatric anxiety disorders, linked to diagnosis and poorer CBT outcomes, offering potential for patient stratification and novel intervention target
A large retrospective cohort study found no significant association between perinatal or early infant antibiotic exposure and subsequent hospitalization for infections in early childhood, providing reassurance about the cautious use of anti
State-level repeal of nonmedical vaccine exemptions significantly improves kindergarten vaccination rates across multiple vaccines, with minimal increase in medical exemptions, highlighting its role in sustaining herd immunity amid growing
An emotion-focused parenting intervention improves prefrontal cortex activation during emotion regulation in adolescent girls with internalizing symptoms, correlating with reductions in maternal unsupportive socialization and adolescent anx
A novel pediatric-specific atlas of US acute care regions was developed using Medicaid data, revealing distinct patterns in emergency and referral care and providing a foundation for targeted pediatric healthcare planning and quality improv
This study reveals multiple distinct molecular mechanisms, including epithelial and macrophage pathways, that contribute to residual asthma exacerbations in children treated with mepolizumab, highlighting the complexity of airway inflammati
Prompt opioid delivery in pediatric EDs for sickle cell pain significantly lowers hospitalization rates, with the greatest benefit seen when the first dose is given within 60 minutes and the second dose within 30 minutes.
A Spanish multicenter study reveals a sharp rise in pediatric invasive group A streptococcal infections and severity after 2022, highlighting emm1 strain predominance and risk factors for critical illness and mortality.
A comprehensive study identifies key clinical and temporal risk factors associated with severe invasive group A streptococcal disease in children, highlighting increased severity and incidence post-COVID-19 pandemic in the Netherlands.
This study explores how early Epstein-Barr virus (EBV) infection and immune responses influence oral human papillomavirus (HPV) infections in children, revealing the interplay between EBV serology, paternal education, and oral HPV acquisiti
This study links EBV seropositivity to immune dysregulation and increased mortality in pediatric sepsis, highlighting potential pathways for targeted therapies.
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