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HEARTBiT, a novel transcriptomic biomarker, effectively detects moderate-to-severe acute cellular rejection within the first year after heart transplantation, offering a minimally invasive alternative to biopsy, especially during the high-r
This study reveals significant discordance between HER2 scores from endometrial biopsy samples and hysterectomy specimens using gastric scoring criteria, impacting treatment decisions in high-grade endometrial cancer.
Peritoneal fluid-derived small extracellular vesicles exhibit distinct proteomic profiles in endometriosis, identifying potential biomarkers for improved diagnosis independent of cycle phase or disease stage.
Long-read sequencing (LRS) improves genetic diagnosis of Congenital Adrenal Hyperplasia and other DSDs by resolving complex genomic variants, tightening phenotype-genotype correlations, and closing equity gaps in clinical care.
This study clinically validates an AI-based quantitative tool, CIF, for bone marrow fibrosis assessment, demonstrating improved reproducibility and accuracy over manual grading without increasing assessment time.
This study evaluates how different pituitary adenoma histological subtypes influence remission and disease control in acromegaly post-surgery, finding no significant differences though sparsely granulated adenomas show a trend toward lower
A stakeholder consensus sets a roadmap to develop standardized, age- and sex-specific testosterone reference intervals for women, adolescent girls, and children to improve diagnosis and care for androgen-related disorders.
A retrospective cohort study at a safety-net hospital found that routine pathological examination of tonsillectomy specimens rarely reveals unexpected malignancies, supporting targeted pathology based on clinical assessment.
Large-scale proteomic analysis identifies novel maternal plasma protein biomarkers that improve detection of fetal death beyond established markers, highlighting both shared and unique pathological pathways with preeclampsia.
Detection of genomic alterations via Afirma Xpression Atlas in indeterminate thyroid nodules enhances malignancy risk stratification beyond Afirma GSC results, guiding surgical decision-making.
DNA methylation profiling in AML patients reveals epigenetic subtypes that mirror genetic mutations, improving risk stratification and outcome prediction beyond standard genetic markers.
Narrow-band imaging (NBI) significantly improves the endoscopic differentiation of inverted papillomas (IPs) from nasal polyps (NPs) by highlighting mucosal microvasculature patterns, achieving superior diagnostic accuracy compared to white
This study demonstrates that fetal fraction amplification significantly improves cell-free DNA screening feasibility as early as 7 3/7 weeks gestation, maintaining high accuracy and low failure rates, potentially transforming early prenatal
A recent study comparing tissue-free and tumor-informed ctDNA assays in early triple negative breast cancer reveals comparable accuracy and earlier detection of molecular residual disease, supporting tissue-free approaches for routine clini
The ELN‑DAVID 2026 technical note establishes standards for NGS-based detection of FLT3‑ITD measurable residual disease (MRD) in AML, with lab validation, reporting, timing, and clinical-use recommendations to make FLT3‑ITD MRD testing acti
A novel enzymatic assay measuring fasting 2-hydroxybutyrate shows high accuracy in identifying postprandial dysglycemia in individuals with normal fasting glucose and HbA1c, offering an improved screening approach for early glucose metaboli
This study identifies distinct tumor immune microenvironment subgroups in diffuse large B-cell lymphoma based on CD163 and CD11c expression, revealing prognostic significance and potential therapeutic stratification with checkpoint inhibito
This study refines the classification of PIEZO1 variants using integrative genomic and phenotypic data, enhancing diagnosis and personalized management of hereditary red blood cell and iron disorders like dehydrated hereditary stomatocytosi
A cluster randomized trial in Toronto nursing homes found that on-site multiplex PCR testing improved viral detection and reduced emergency department transfers during respiratory outbreaks, though it did not alter outbreak size or frequenc
Combining circulating methylated SEPT9 with alpha-fetoprotein significantly enhances early hepatocellular carcinoma detection in cirrhotic patients, outperforming AFP alone and allowing improved surveillance sensitivity and specificity.
