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A biomarker-based ABC-AF risk score-guided treatment did not improve stroke or death outcomes versus standard care in atrial fibrillation, underscoring the need for prospective validation of precision medicine tools before clinical implemen
This article elucidates VO2T12.5% as a new, practical oxygen uptake recovery measure reflecting cardiac function and prognosis in heart failure and obstructive hypertrophic cardiomyopathy, validated in robust clinical cohorts including the
Pretreatment circulating tumor DNA levels can predict which patients with advanced ER-positive, HER2-negative breast cancer benefit more from first-line CDK4/6 inhibitor therapy, supporting personalized treatment strategies.
New research identifies a protein signature in blood that detects ALS years before symptoms, challenging previous perceptions and offering hope for early diagnosis and intervention.
A large population-based genetic study clarifies the associations of rare pathogenic variants in established cancer predisposition genes with the risk of single and multiple primary cancers, supporting multigene panel testing in affected in
A secondary analysis of the SAMCO-PRODIGE 54 trial reveals that early changes in circulating tumor DNA predict long-term outcomes in dMMR/MSI-H metastatic colorectal cancer patients treated with immune checkpoint inhibitors.
This systematic review and meta-analysis evaluates NT-proBNP’s accuracy in predicting mortality among ischemic stroke patients, revealing moderate to high prognostic performance with potential clinical utility in risk stratification.
Elevated hs-cTnI levels below myocardial injury thresholds associate with increased late-life dementia risk in older women, highlighting cardiovascular biomarkers’ potential to identify vulnerable individuals for dementia prevention.
A proof-of-concept study demonstrates that AI-based image recognition, using the ResNet-18 algorithm, can accurately identify clinically important Aspergillus species, offering a rapid, cost-effective alternative to traditional methods.
A large international study reveals unique somatic mutation profiles and higher mutational burden in hypermutated early-onset colorectal cancer, highlighting the need for age-specific molecular diagnostics and management strategies.
Systemically biased AI models can reduce clinicians’ diagnostic accuracy, and explanations alone may not mitigate this harm, according to a multicenter study involving over 450 clinicians.
The complete blood count (CBC) is a routine yet powerful tool that reveals crucial information about your health. Learn what it really tells us, common misunderstandings, and how to make the most of this essential test.
